Therapeutic Peptides and Proteins
Crc Press Inc (Verlag)
978-0-8493-1630-2 (ISBN)
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Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up-to-date, relevant information on protein formulation and/or delivery systems and the need for a new edition is self-evident. This second edition continues the tradition of providing a ready-to-use reference of accurate information, tables, and illustrations. The book begins with the basics of the origin of recombinant proteins, explores structural and analytical aspects, and moves on to discuss the stability of proteins and peptides. Against this background, the author addresses preformulation and formulation considerations and provides detailed information on important topics such as lyophilization. He goes on to discuss various delivery systems, including controlled release delivery systems and products currently on the market. The book also contains newly added regulatory information and thoroughly investigates therapeutic drugs made from proteins as well as protein-based vaccines. A new chapter on recombinant protein subunit vaccines and their delivery systems has been added.
The work of a single author, the book provides complex information in a simple, elegant, and cohesive style. The author minimizes overlap between coverage and includes extensive cross-referencing that links related topics. Completely revised and updated, packed with cutting-edge information, the second edition once again fills the need for a reference that pulls all the relevant information together into one resource.
Pharmaceutical Biotechnology: The Arrival of Recombinant Proteins
What is Biotechnology
The Biotechnology Industry
Regulatory Aspects of Biotechnology-Derived Drugs
Immunogenicity of Proteins
Structure-Based Drug Design
Conclusions
Structure and Analysis of Therapeutic Peptides and Proteins
Amino Acids: Building Blocks of Proteins
Structure of Peptides and Proteins
Protein Conformation and Other Structural Features
Analytical Methods
Conclusions
Stability of Therapeutic Peptides and Proteins
Introduction
Physical Instability
Chemical instability
Well-Characterized Products and Comparability Protocols
Conclusions
Preformulation and Formulation of Therapeutic Peptides and Proteins
Introduction
Preformulation Studies
Formulation Development
Pharmaceutical Excipients in Formulations
Aggregation in Protein Formulations
Novel Formulation Approaches
Accelerated Stability Testing
Statistical Design for Formulation Development
Conclusions
Lyophilization, Pharmaceutical Processing, and Handling of Therapeutic Peptides and Proteins
Introduction
Protein Destabilization Induced by Pharmaceutical Processing
Lyophilization as a Pharmaceutical Process
Alternative Pharmaceutical Processes
Handling of Therapeutic Peptides and Proteins
Conclusions
Parenteral Controlled Delivery and Pharmacokinetics of Therapeutic Peptides and Proteins
Introduction
Pharmacokinetics of Peptide and Protein Drugs
Polymers Used for Controlled Delivery of Peptides and Proteins
Parenteral Controlled Release Systems
Innovations in Parenteral Administration of Proteins
Examples of Protein Pharmacokinetics
Conclusions
Oral Delivery of Peptide and Protein Drugs
Introduction
Barriers to Protein Absorption and Pathways of Penetration
Approaches to Improve Oral Delivery
Methods to Study Oral Absorption
Oral Immunization
Conclusions
Transdermal and Topical Delivery of Therapeutic Peptides and Proteins
Introduction
Skin Structure
Approaches to Enhance Transdermal Peptide Delivery
Iontophoresis
Topical Delivery of Therapeutic Peptides and Proteins
Conclusions
Pulmonary and Other Mucosal Delivery of Therapeutic Peptides and Proteins
Introduction
Pulmonary Delivery
Nasal Delivery
Rectal Delivery
Buccal Delivery
Ocular Delivery
Comparative Evaluation of Mucosal Routes
Conclusions
Recombinant Protein Subunit Vaccines and Delivery Methods
Introduction
Immunology Relevant to Vaccines
Routes of Administration
Delivery Approaches for Administration of Vaccines
Case example: Hepatitis B
Future Outlook and Regulatory Status
Conclusions
| Erscheint lt. Verlag | 14.9.2005 |
|---|---|
| Zusatzinfo | 8 Tables, black and white; 12 Illustrations, black and white |
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 235 mm |
| Gewicht | 680 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| ISBN-10 | 0-8493-1630-8 / 0849316308 |
| ISBN-13 | 978-0-8493-1630-2 / 9780849316302 |
| Zustand | Neuware |
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