Formulating Poorly Water Soluble Drugs
Springer International Publishing (Verlag)
978-3-030-88721-6 (ISBN)
Robert O. (Bill) Williams is the Johnson & Johnson Centennial Chair and Professor of Pharmaceutics and the Division Head of Molecular Pharmaceutics and Drug Delivery at the College of Pharmacy, University of Texas at Austin. He earned a B.S. in Biology from Texas A&M University, a B.S. in Pharmacy from the University of Texas at Austin and Doctor of Philosophy in Pharmaceutics in 1986 from the University of Texas at Austin. Dr. Williams worked 9 years in the pharmaceutical industry in the United States and France before returning to the University of Texas at Austin in 1995. Dr Williams was elected Fellow of the American Association of Pharmaceutical Scientists in 2006, Fellow of the American Institute of Medical and Biological Engineering in 2008 and Fellow of the National Academy of Inventors in 2019. He was named the Inventor of the Year by the University of Texas at Austin in 2017. Dr. Williams is a member of the American Association of Pharmaceutical Scientists (AAPS), as well as other professional societies including the American Association of Colleges of Pharmacy. He is the co-founder of several pharmaceutical companies. Dr. Williams' research interests include development of novel drug delivery systems for oral, pulmonary, nasal, injectable, buccal and topical applications, development of novel particle engineering technologies for low molecular weight drugs, peptides and proteins, and analytical technologies to characterize actives, excipients and polymers. He has published over 500 peer-reviewed research articles, reviews, abstracts and book chapters, and co-edited two books in the fields of pharmaceutical technology and drug delivery, including Formulating Poorly Water Soluble Drugs, Second Edition (aapspress and Springer). He is an inventor on over 45 patents and patent applications. Dr. Williams served as Editor-in-Chief of the research journal Drug Development and Industrial Pharmacy from 2000 to 2014 and is the Editor-in-Chief of AAPS PharmSciTech since 2014. He is on the Editorial Advisory Board of Journal of Drug Delivery Science and Technology and International Journal of Pharmaceutics and he serves as a reviewer for numerous other journals.
Daniel Alan Davis, Jr., Ph.D., Pharm.D.Daniel Davis received his BS in Chemistry from the University of Texas at Austin in 2015 and PharmD from the University of Texas at Austin College of Pharmacy (UTCOP) in 2019, where he graduated with research honors and academic honors. His research contributions resulted in him receiving the prestigious College of Pharmacy's Outstanding Research Award. Daniel completed his Ph.D. in 2021 as part of the PharmD/PhD Honor's program in the Division of Molecular Pharmaceutics and Drug Delivery, and currently works as an associate principal scientist at DisperSol Technologies, LLC. Daniel has Authored six peer-reviewed publications, co-authored three peer-reviewed publications and eight published abstracts at international pharmaceutical conferences in the area of drug solubilization and amorphous solid dispersions, and he is an inventor on eight patents and patent applications. His research is focused on increasing the solubility of poorly water soluble drugs, specifically focused on innovation formulation designs for increased solubility. Much of this work uses KinetiSol processing, hot melt extrusion and selective laser sintering three-dimensional printing. Daniel received the B. Berard Matthews Endowed Scholarship, the Van Smith Endowed Presidential Scholarship, and the Undergraduate Research Fellowship from the University of Texas at Austin based on his research. Daniel serves as the social media editor for AAPS PharmSciTech and a peer reviewer for the International Journal of Pharmaceutics.
Dave A. Miller, Ph.D. is the Chief Scientific Officer at DisperSol Technologies. Prior to his current position, Dr. Miller served
Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs.- Optimizing the Formulation of Poorly Water-Soluble Drugs.- Solid-State Techniques for Improving Solubility.- Mechanical Particle-Size Reduction Techniques.- Co-solvent and Complexation Systems.- Injectable Formulations of Poorly Water-Soluble Drugs.- Lipid-Based Formulations.- Structured Development Approach for Amorphous Systems.- Melt Extrusion.- Spray-Drying Technology.- Pharmaceutical Cryogenic Technologies.- Precipitation Technologies for Nanoparticle Production.- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs.- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
| Erscheinungsdatum | 21.05.2023 |
|---|---|
| Reihe/Serie | AAPS Advances in the Pharmaceutical Sciences Series |
| Zusatzinfo | XII, 693 p. 280 illus., 138 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 1326 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Technik | |
| Schlagworte | amorphous systems • Bioavailability • Dissolution • Drug Delivery • drug dosage design • formulation development • lipophilic • nanoparticle processes • route-specific challenges • Solubility |
| ISBN-10 | 3-030-88721-9 / 3030887219 |
| ISBN-13 | 978-3-030-88721-6 / 9783030887216 |
| Zustand | Neuware |
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