Temperature and Toxicology

An Integrative, Comparative, and Environmental Approach

Christopher J. Gordon (Autor)

Buch | Hardcover

356 Seiten

2005
Crc Press Inc (Verlag)
978-0-8493-3024-7 (ISBN)

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Thermoregulation is vital for survival but the interplay between toxic insults and thermoregulatory mechanisms is often poorly understood. Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach is the first major text to study the integrative thermoregulatory responses of mammals that are exposed to toxicants. Because environmental physiology is also crucial in toxicological responses, this volume also examines the role of environmental temperature in the modulation of cellular mechanisms of toxicity.

The book begins by explaining the importance of temperature in toxicological studies, and how all biological processes are dependent on temperature. It then reviews the basics of temperature regulation in homeotherms and poikilotherms, and addresses whole-animal and in vitro studies related to the effects of temperature on toxicity. The text examines thermoregulatory response to toxic insult, and how responses affect recovery and potential survival. It describes hypothermic response in rodents to febrile and hyperthermic reactions in humans, and discusses the relevance of heat and cold stress on human exposures to airborne pollutants and other toxicants.

This volume provides an extensive comparison of physiological responses of invertebrates, fish, amphibians, and mammals, and focuses on the impact of endocrine disruption. It then considers how toxicants and thermal stress cause the expression of stress proteins, followed by a study of the impact of genetic variability. The book concludes with an examination of thermoregulatory response to natural toxins and venoms.

Christopher J. Gordon

Introduction. Principles of temperature regulation. Acute toxic thermoregulatory responses. Temperature effects on chemical toxicity. Regulated hypothermia: An adaptive response to toxic insult. Fever and hyperthermia. Environmental stress. Comparative physiological responses. Genetic variability and molecular markers. Toxins and venoms.

Erscheint lt. Verlag	28.2.2005
Zusatzinfo	24 Tables, black and white; 107 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	156 x 234 mm
Gewicht	612 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-8493-3024-6 / 0849330246
ISBN-13	978-0-8493-3024-7 / 9780849330247
Zustand	Neuware