Inflammatory Bowel Disease

Crossroads of Microbes, Epithelium and Immune Systems

Derek J. Chadwick, Jamie A. Goode (Herausgeber)

Buch | Hardcover

240 Seiten

2004
John Wiley & Sons Inc (Verlag)
978-0-470-09046-6 (ISBN)

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Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as:

Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival
The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy
The progress towards the identification of susceptibility genes and phenotype-determining genes
The pharmacogenetics of IBD
Mucosal immunology and therapeutic strategies stemming therefrom

Derek J. Chadwick and Jamie A. Goode are editors for Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems and other scientific titles.

Chair's Introduction (Jewell). Progress toward identifying inflammatory bowel disease susceptibility genes (Rioux).

Phenotype-determining genes in inflammatory bowel disease (Ahmad).

Pharmacogenetics of inflammatory bowel disease (Kelleher et al).

Bacterial milieu and mucosal bacteria in ulcerative colitis (Macfarlane et al).

Defensins and mucosal protection (Mahid and Cunliffe).

Intestinal mycoplasma in Crohn's Disease (Roediger).

Kong Probiotics, prebiotics and antibiotics in inflammatory bowel disease (Cummings and Choon).

The eipthelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption (Ivanov et al).

Apoptosis or necrosis - colonic epithelial cell survival (Gibson).

Genetic aspects of intestinal permeability in inflammatory bowel disease (Takeuchi et al).

Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease (Powrie and Uhlig).

Homing of intestinal immune cells (Uhlig et al).

Anti-TNF therapy in Crohn's Disease (Ghosh).

Index of contributors.

Subject index.

Erscheint lt. Verlag	12.11.2004
Reihe/Serie	Crossroads of Microbes, Epithelium and Immune Systems ; No.263
Verlagsort	New York
Sprache	englisch
Maße	160 x 236 mm
Gewicht	508 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	0-470-09046-4 / 0470090464
ISBN-13	978-0-470-09046-6 / 9780470090466
Zustand	Neuware