Targeting Oncogenic Driver Mutations in Lung Cancer

Matthew Lee, Fawzi Abu Rous, Alain Borczuk, Stephen Liu, Shirish Gadgeel (Autoren)

Buch | Softcover

75 Seiten

2023
Cambridge University Press (Verlag)
978-1-009-33613-0 (ISBN)

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The recent advances in the field of molecular diagnostic techniques have led to the identification of targetable alterations prompting a paradigm shift in the management of non-small cell lung cancer (NSCLC) and an era of precision oncology. This Element highlights the most clinically relevant oncogenic drivers other than EGFR, their management and current advancements in treatment. It also examines the different challenges in resistance to targeted therapies and diagnostic dilemmas for each oncogenic driver and the future direction of NSCLC management.

1. Introduction; 2. ALK gene rearrangements; 3. ROSI gene rearrangements; 4. RET gene rearrangements; 5. MET alterations; 6. KRAS point mutations; 7. B-RAF point mutations; 8. NTRK1/2/3 gene fusions; 9. ERBB2 (HER2) mutations; 10. Diagnostic strategies; References.

Erscheinungsdatum	23.01.2023
Reihe/Serie	Elements in Molecular Oncology
Zusatzinfo	Worked examples or Exercises
Verlagsort	Cambridge
Sprache	englisch
Maße	152 x 227 mm
Gewicht	160 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
ISBN-10	1-009-33613-4 / 1009336134
ISBN-13	978-1-009-33613-0 / 9781009336130
Zustand	Neuware