Nematodes as Model Organisms (eBook)

Itamar Glazer, D Shapiro-llan, Paul W. Sternberg (Herausgeber)

eBook Download: EPUB

2022
376 Seiten
CABI (Verlag)
978-1-78924-881-4 (ISBN)

Infos

Nematodes, especially Caenorhabditis elegans have been used as a model for research in molecular biology since the 1960s. This is a much-needed update on research on fundamental processes in areas such as genetics, developmental biology, nutrition, toxicology, ecology, pharmacology and medicine.

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Nematodes are small multicellular organisms that have been used as biological models since the 1960s. For example, Caenorhabditis elegans is a free-living nematode worm, about 1mm in length, that lives in temperate soil environments. It is made up of about 1000 cells, and has a short life cycle of only two weeks. It was the first multicellular organism to have its whole genome sequenced.

The book summarizes the importance of nematodes as model organisms in the fields of genetics, developmental biology, neurobiology, pharmacology, nutrition, ecology and parasitology.

Of interest to a broad audience across a wide spectrum of disciplines, this book is useful for biologists working on comparative studies to investigate biological processes across organisms; medical scientists and pharmacologists for exploration of drugs and medicine (including the use of genome editing to eliminate diseases); ecologists considering nematodes as indicators for environment changes; and parasitologists for host-parasite interactions. Many other researchers can use this book as a benchmark for the broad implications of nematology research on other aspects of science.

Autor

Itamar Glazer (Edited By) Itamar Glazer is Researcher at the Agricultural Research Organization (ARO), Volcani Center, Israel.David I Shapiro-llan (Edited By) David Shapiro-Ilan is a Supervisory Research Entomologist at USDA-ARS, Georgia, USA. Dr. Shapiro-Ilan's research focuses on invertebrate pathology/microbial control. Areas of interest emphasize the study of entomopathogenic nematodes and include biological control applications, production and formulation technology, and studies on nematode behavior (especially foraging dynamics). Dr. Shapiro-Ilan has published 180 peer-reviewed journal articles plus 24 book chapters and > 40 trade journal/extension articles; he has co-edited 3 books and is inventor on 7 patents. Selected awards include Fellow of the Society of Nematologists, EEO/Civil Rights, Excellence in IPM (SEB-ESA, 2012), and > $7 million as PI/co-PI on competitive grants. He is currently the Editor-in-Chief for the Journal of Nematology, and Editor for the Journal of Invertebrate Pathology.Paul W. Sternberg (Edited By) Paul Sternberg is Professor of Biology at Caltech, USA.

Rezensionen

These studies take advantage of molecular genetics and genomics work on the symbiotic bacteria; e.g., bacterial mutants affecting colonization of the infective-stage nematode inform us about the genes responsible for colonization. This chapter also reviews how C. elegans serves a model to study gutmicrobiome regulation and other cases in which endosymbionts (e.g., Wolbachia bacteria) significantly impact nematode fitness and are thus potential targets for therapeutics against parasitic nematodes. Other chapters explore equally fascinating as well as practically important topics such as interactions between nematodes and plants and animals, roles of nematodes in ecological systems (e.g. soil), the use of nematodes as indicators of ecosystem state, pharmacology and toxicology in nematodes, and stress and survival mechanisms such as cryptobiosis.

In summary, this very readable book will be of interest not only to nematologists and C. elegans specialists who want to broaden their perspectives on how nematodes have impacted various fields, but also to other biologists, medical scientists, pharmacologists, educators, naturalists, and citizen scientists who want to feed their curiosity about many of life's mysteries and how they are being addressed through the vast and growing toolkit provided by nematodes.

Produkt-Details

• Erscheint lt. Verlag: 17.6.2022
• Co-Autor: Sigal Braun Miyara, Fernando Calahorro, Raquel Campos-Herrera, Ioannis Eleftherianos, James Dillon, Katarzyna Dudkiewicz, Birgit Gansfort, Heidi Goodrich-Blair, Alex S. Grossman, Selcuk Hazir, Jennifer K. Heppert, Ivan Hiltpold, Lindy Holden-Dye, Sebastian Höss, Anil Kumar, Emilie Lefoulon, Edwin E. Lewis, James W. Lightfoot, Terra J. Mauer, Vincent O’Connor, Ratnasri Pothula, Elizabeth M. Ransone, Sara Sánchez Moreno, Glen Stevens, Ralf J. Sommer, S. Patricia Stock, Ghada Tafesh-Edwards, Heidi A. Tissenbaum, Walter Traunspurger, Robert J Walker, Dayong Wang
• Verlagsort: Oxford
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
• Themenwelt: Naturwissenschaften ► Geowissenschaften
• Schlagworte: Caenorhabditis elegans • C. elegans • model organism • nematode aging • nematode environmental indicator • nematode genetics research • nematodes as biological models
• ISBN-10: 1-78924-881-7 / 1789248817
• ISBN-13: 978-1-78924-881-4 / 9781789248814