Genetics of Substance Use

Research and Clinical Aspects

Buch | Softcover

XII, 230 Seiten

2022 | 1st ed. 2022
Springer International Publishing (Verlag)
978-3-030-95349-2 (ISBN)

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The book illuminates the complex problems in genetic studies of substance use and addiction. It provides a comprehensive overview that fills the gap in the literature and points out future directions.

The book includes three sections that apply to any complex traits and disorders, particularly psychological and psychiatric. The first section covers the traits and phenotypes that are the target of genetic research in substance use and addiction. Following this, the second section analyzes the methods and results of biometric genetic studies in this area. The third section reviews research in gene mapping and epigenetics.

Genetics of Substance Use is a first-of-its-kind monograph that presents contemporary solutions and methods for a wide range of researchers and practitioners across disciplines.

lt;p>Michael M. Vanyukov

University of Pittsburgh

06353 Salk Hall

Pittsburgh, PA 15261

email: mmv@pitt.edu

Michael M. Vanyukov, Ph.D., is Professor of Pharmaceutical Sciences, Psychiatry, and Human Genetics at the University of Pittsburgh. He was trained as a geneticist at the M. V. Lomonosov Moscow State University, Moscow, USSR, and received his Ph.D. in genetics from the USSR Academy of Medical Sciences Institute of Medical Genetics. After his immigration in the USA, he was a postdoctoral fellow in psychiatry at Western Psychiatric Institute and Clinic, Pittsburgh, PA. He has contributed to the NIH-funded longitudinal study of addiction etiology, Center for Education and Drug Abuse Research (CEDAR), a NIDA Center of Excellence at the University of Pittsburgh, leading its research program as its scientific director and director of its neurogenetics research project for over 15 years. As investigator, mentor, and consultant, he has laid the groundwork for genetic research extensively examining major neurobiological systems, combining hypothesis-driven approach, a wide scope of genetic coverage, and biological and psychological mechanisms and mediators of addiction liability. Genotype-environment interaction in the development of liability phenotype is one of the aspects of this research. He has also pioneered phenotypic measurement methodology for complex psychological and psychiatric traits, maximizing its informativeness. This work has recently been focused on the reversal of the common biomedical research perspective, from disease risk to potentially more practicable resistance to disorder, its measurement, and search for resistance factors.

S ubstance use phenotyping.- Substance use: disorders and continuous traits.- Neurobiological systems in substance use.- Psychological mechanisms of substance use.- Biometric genetic studies in substance use.- Twin studies.- Family and adoption studies.- Genomic studies in substance use.- Gene mapping in complex disorders.- Linkage and association studies.- Epigenomic studies.- Conclusions

Erscheinungsdatum	31.03.2022
Zusatzinfo	XII, 230 p. 18 illus., 11 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	178 x 254 mm
Gewicht	573 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Schlagworte	addiction • Genetics • genomics • Psychiatry • Psychology • substance abuse
ISBN-10	3-030-95349-1 / 3030953491
ISBN-13	978-3-030-95349-2 / 9783030953492
Zustand	Neuware