3D Lung Models for Regenerating Lung Tissue

Gunilla Westergren-Thorsson, Sara Rolandsson Enes (Herausgeber)

Buch | Softcover

260 Seiten

2022
Academic Press Inc (Verlag)
978-0-323-90871-9 (ISBN)

Artikel merken

3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition.

Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field.

Professor in lung biology with a specific focus on extracellular matrix linked to structural changes and lung function in human chronic lung diseases. During the past decade, her research focus has shifted more towards developing human 3D lung model systems and bioreactors. She was the Dean of the Medical Department at Lund University for 6 years, and one of the chairs of the national board of SciLifeLab, working with infrastructure in Life Science at a national level to facilitate the use and edge of different techniques. Dr. Enes is an associated researcher in lung biology with a specific focus on stem cells and their interactions with the microenvironment. During the recent years, her research focus has been on how the microenvironment affects the biology and function of stem cells and how this knowledge could be applied to improve cell therapy. In 2019, she was involved in putting together and leading a session on the topic “From 2D to 3D models of human lung disease: novel developments to rebuild the lung for the large European Respiratory Society (ERS) annual congress. In addition, she was invited to write a landmark paper on bioartificial lungs.

Part I: Standard 2D culture on plastic 1. 2D culture on plastic, past, present, important findings and breakthroughs 2. The importance of microenvironment (ECM, GAG)

Part II: 3D lung models 3. ALI model 4. Biofilms 5. Lung organoid models 6. 3D models Artificial material 7. 3D extracellular matrix models 8. Lung-on-a-chip 9. Flow, Mechanical properties, and bioreactors 10. Challenges with 3D models and Future directions

Part III: New directions 11. 3D printing and bioprinting 12. Drug-screening and high throughput in 3D lung models 13. Model validation 14. AI and computational modelling 15. Conclusions

Erscheinungsdatum	19.08.2022
Zusatzinfo	Approx. 100 illustrations (100 in full color); Illustrations
Verlagsort	Oxford
Sprache	englisch
Maße	191 x 235 mm
Gewicht	540 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	0-323-90871-3 / 0323908713
ISBN-13	978-0-323-90871-9 / 9780323908719
Zustand	Neuware