Circadian Pharmacokinetics

Baojian Wu, Danyi Lu, Dong Dong (Herausgeber)

Buch | Softcover

253 Seiten

2021 | 1st ed. 2020
Springer Verlag, Singapore
978-981-15-8809-9 (ISBN)

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This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Dr. Baojian Wu is a professor at the College of Pharmacy, Jinan University, China. He obtained his Ph.D. from University of Houston in 2011 and completed his post-doctoral training at the Baylor College of Medicine from 2011 to 2012. His research focuses on circadian regulation of drug metabolism and transport, as well as circadian regulation of inflammatory and metabolic diseases, fields in which he has published more than 100 research articles. Dr. Danyi Lu is an associate professor at the College of Pharmacy, Jinan University, China. Dr. Dong Dong is an associate professor at the College of Medicine, Jinan University, China..

Chapter 1. Introduction to mammalian circadian clock system.- Chapter 2. Introduction to pharmacokinetics.- Chapter 3. Circadian clock and metabolic diseases.- Chapter 4. Circadian clock and CYP metabolism.- Chapter 5. Circadian clock and non-CYP phase I metabolism.- Chapter 6. Circadian clock and phase II metabolism.- Chapter 7. Circadian clock and uptake transporters.- Chapter 8. Circadian clock and efflux transporters.- Chapter 9. Role of pharmacokinetics in chronotherapeutics.- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.

Erscheinungsdatum	08.11.2021
Zusatzinfo	46 Illustrations, color; 13 Illustrations, black and white; VII, 253 p. 59 illus., 46 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
Schlagworte	chronotherapeutics • Circadian clock • Drug-metabolizing enzymes • Pharmacokinetics • Uptake and efflux transporters
ISBN-10	981-15-8809-0 / 9811588090
ISBN-13	978-981-15-8809-9 / 9789811588099
Zustand	Neuware