Antimalarial Natural Products

A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch (Herausgeber)

Buch | Hardcover

IX, 106 Seiten

2022 | 1st ed. 2022
Springer International Publishing (Verlag)
978-3-030-89872-4 (ISBN)

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This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.

Chapter 1. Antimalarial Natural Products.

Erscheinungsdatum	05.01.2022
Reihe/Serie	Progress in the Chemistry of Organic Natural Products
Zusatzinfo	IX, 106 p. 112 illus., 8 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	304 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Alkaloids • Artemisinin • Malaria • Mechanism of Action • Plasmodium Falciparum • quinine • terpenoids
ISBN-10	3-030-89872-5 / 3030898725
ISBN-13	978-3-030-89872-4 / 9783030898724
Zustand	Neuware