I Domains in Integrins

Buch | Hardcover

186 Seiten

2003
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-47836-9 (ISBN)

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In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.
This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.

Preface. 1. Evolution of Integrin I-Domains; M.S. Johnson, D. Tuckwell. 2. Integrin alpha1beta1; H. Gardner. 3. Function of alpha2beta1 Integrin; M.M. Zutter, S.A. Santoro. 4. Structure Distribution and Function of alpha10beta1 Integrin; E. Lundgren-Akerlund, M. Schneller. 5. Structure and Function of alpha11beta1 Integrin; D. Gullberg, S.N. Popova, C.-F. Tiger. 6. Structure and Activation of beta2-Integrins; C.G. Gahmberg, S. Fagerholm. 7. Integrin alphaEbeta7: Molecular Features and Functional Significance in the Immune System; P.J. Kilshaw, J.M.G. Higgins. 8. Structural Aspects of Integrins; R.C. Liddington. 9. Integrin Recognition Motifs in Collagens; R.W. Farndale. 10. Cellular Signaling by Collagen-Binding Integrins; J. Heino. 11. Collagen-Binding Integrins and Disease; B. Eckes, B. Nieswandt, T. Krieg. 12. Integrins in Immune and Inflammatory Disease; A.R. de Fougerolles. Index.

Erscheint lt. Verlag	31.7.2003
Reihe/Serie	Molecular Biology Intelligence Unit
Zusatzinfo	X, 186 p.
Verlagsort	New York
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-306-47836-6 / 0306478366
ISBN-13	978-0-306-47836-9 / 9780306478369
Zustand	Neuware