Essential Hypertension and Its Causes

Neural and Non-Neural Mechanisms

Paul I. Korner (Autor)

Buch | Hardcover

720 Seiten

2007
Oxford University Press Inc (Verlag)
978-0-19-509483-1 (ISBN)

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Essential hypertension (EH) is the most common type of high blood pressure and is responsible for much death and serious illness, which has been the reason for the huge research effort to determine its causes. However, countless scientific articles still keep proclaiming that "the causes of essential hypertension remain unknown." In view of the number of publications that descend on the hypertension specialist like a waterfall, such proclamations seem to overlook the considerable amount of knowledge that we already have about the etiology of EH. The problem may be a lack of synthesis rather than a lack of information. This book provides a unique synthesis of the pathophysiology of essential hypertension (EH), which is limited through the brain and is critically dependent on both genetic and environmental factors such as stress, high salt intake and obesity. Korner analyses the mechanisms by which the various factors raise blood pressure and the pathophysiology of EH compared with that in renal hypertension and in some of the rat models of genetic hypertension. In some individuals stress-induced vasoconstriction enhances the brain's responsiveness to salt, giving rise to stress-and-salt-related EH. In others, stress-induced EH promotes eating, causing hypertensive obesity. Improving lifestyle through regular exercise and reduction of salt and calorie intake directly antagonises the environmental causes of EH, and has implications for prevenion and treatment.

Paul Korner is Emeritus Professor of Medicine, Monash University, and Emeritus Director of the Baker Medical Research Institute. He was Foundation Professor of Physiology, University of New South Wales (1960-68); Scandrett Professor of Cardiology, University of Sydney (1968-1974); Director of the Baker Medical Research Institute and Professor of Medicine, Monash University (1975-1990).

I. INTRODUCTION ; II. BIOLOGICAL CONTROL ; III. INPUT-OUTPUT ANALYSIS: POINTERS TO NEURAL INVOLVEMENT ; IV. INTRINSIC CARDIOVASCULAR PROPERTIES IN HYPERTENSION ; V. INTERACTIVE ASPECTS OF NEURAL CIRCULATORY CONTROL ; VI. THE BRAIN AS THE SOURCE OF LIFESTYLE-RELATED HYPERTENSION ; VII. CAUSES AND MECHANISMS OF RENAL AND SHR HYPERTENSION ; VIII. SYNTHESIS

Erscheint lt. Verlag	17.5.2007
Zusatzinfo	270 illustrations
Verlagsort	New York
Sprache	englisch
Maße	164 x 240 mm
Gewicht	1161 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
ISBN-10	0-19-509483-2 / 0195094832
ISBN-13	978-0-19-509483-1 / 9780195094831
Zustand	Neuware