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Medical Defense Against Mustard Gas

Toxic Mechanisms and Pharmacological Implications

Alan J. Feister (Autor)

Buch | Hardcover

376 Seiten

1991
Crc Press Inc (Verlag)
978-0-8493-4257-8 (ISBN)

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This book provides a comprehensive review and analysis of the acute toxic effects of sulfur mustard (mustard gas); the injuries that this compound produces in skin, eye, airway, and other tissues; and possibilities for the prevention of these injuries through pharmacological intervention. The book takes a multidisciplinary approach and is intended for all biomedical researchers interested in combatting the effects of chemical weapons, as well as those who have a general interest in the basic processes underlying cell death and tissue injury. Drawing on an extensive base of scientific literature, including many government research reports that are difficult or impossible for most researchers to obtain, the book covers the pathological features of acute mustard injury, sulfur mustard's toxicodynamics, its chemistry, its molecular and cellular mechanisms of injury, the inflammatory mechanisms involved in injury, prophylactic and therapeutic approaches to prevention of injury, and experimental models of mustard injury.

Feister; Alan J. Sci. App. International Corp.,

INTRODUCTION. Historical and Modern Use of Sulfur Mustard in Warfare. History of Research Efforts. The Approach of this Book. CHARACTERIZATION OF INJURIES. THE SULFUR MUSTARD INJURY: DESCRIPTION OF LESIONS AND RESULTING INCAPACITATION. Description of Sulfur Mustard Injuries. Contributions of Skin, Eye, and Respiratory Tract Lesions and Systemic Intoxication to Incapacitation and Death. Conclusions. HISTO- AND CYTOPATHOLOGY OF ACUTE EPITHELIAL LESIONS. Histopathology. Cytopathology. Conclusions.TOXICODYNAMICS OF SULFUR MUSTARD. Exposure Routes of Primary Relevance. Absorption and Distribution. Biotransformation. Excretion. Conclusions. MECHANISMS OF INJURY. CHEMISTRY OF SULFUR MUSTARD. Physical Properties. Chemical Reactions of Sulfur Mustards. Conclusions. GENOTOXICITY AND RELATED CELLULAR EFFECTS OF SULFUR MUSTARD. Inactivation of Bacteriophage. Inactivation of Bacteria and Yeast. Inactivation of Mammalian Cells. Mutagenic and Chromosome-Damaging Effects of Sulfur Mustards. Effects on Gene Expression and Differentiation. Conclusions. MOLECULAR MECHANISMS OF CYTOTOXICITY. The Role of Glycolysis Inhibition in the Cytotoxicity of Sulfur Mustard. Consideration of Dose-Dependent Effects in the Cytotoxicity of Sulfur Mustard. Early Theories of Sulfur Mustard Cytotoxicity: A Historical Perspective. Current Theories of Sulfur Mustard Cytotoxicity. Conclusions. INFLAMMATORY MEDIATORS AND PROTEINASES IN ACUTE EPITHELIAL LESIONS. Mechanisms of Skin Inflammation and Tissue Injury. Mechanisms of Ocular Inflammation and Tissue Injury. Mechanisms of Respiratory Tract Inflammation and Tissue Injury. Conclusions. PREVENTION OF INJURIES. PRETREATMENTS AND THERAPIES. Strategies for Pharmacological Intervention. Compounds Tested Against Sulfur Mustard and Nitrogen Mustard Toxicity. New Directions for Drug Research. Conclusions. EXPERIMENTAL MODELS OF INJURY. EXPERIMENTAL MODELS OF SULFUR MUSTARD INJURY. Cell Toxicity Models. Skin Injury Models. Eye Injury Models. Respiratory Tract Injury Models. Conclusions. GLOSSARY OF ABBREVIATIONS. INDEX.

Erscheint lt. Verlag	3.4.1991
Zusatzinfo	3 Halftones, black and white; 26 Tables, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	178 x 254 mm
Gewicht	1179 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
ISBN-10	0-8493-4257-0 / 0849342570
ISBN-13	978-0-8493-4257-8 / 9780849342578
Zustand	Neuware