Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

Xiucong Bao (Autor)

Buch | Softcover

163 Seiten

2021 | 1st ed. 2020
Springer Verlag, Singapore
978-981-15-2511-7 (ISBN)

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This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.

Introduction to Protein Posttranslational Modifications (PTMs).- Chemical reporter for Lysine Malonylation.- Identification of Histone Lysine Glutarylation.- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly.- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach.

Erscheinungsdatum	26.03.2021
Reihe/Serie	Springer Theses
Zusatzinfo	96 Illustrations, color; 36 Illustrations, black and white; XVIII, 163 p. 132 illus., 96 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Chemical proteomics approach • Chemical Reporter • Chromatin Structure • epigenetics • Histone Posttranslational Modifications • Immunoblotting analysis • metabolic labeling • protein-protein interaction
ISBN-10	981-15-2511-0 / 9811525110
ISBN-13	978-981-15-2511-7 / 9789811525117
Zustand	Neuware