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Regenerative Nephrology

Buch | Hardcover

528 Seiten

2021 | 2nd edition
Academic Press Inc (Verlag)
978-0-12-823318-4 (ISBN)

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Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.

Section 1: Kidney Development and Regeneration

1. Nephrogenesis in Health and Disease

Adrian S. Woolf and Sophie L. Ashley

2. Renal organogenesis in the lymph node microenvironment

Maria Giovanna Francipane

3. In vivo clonal analysis and the kidney: Implications to regenerative nephrology

Oren Pleniceanu Benjamin Dekel

4. Nephrogenesis in malnutrition

Brian B. Ratliff, May M. Rabadi, and Selin Celikoyar

Section 2: Modulators of Regeneration

5. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease

Ross Doyle and Catherine Godson

6. T-cell in kidney injury and regeneration

Li Li, Dylan Baer, and Mark D. Okusa

7. Monocytes and dendritic cells in injury and regeneration

Elise N. Erman, Meryl C. Nath, Matthew D. Cheung, Anupam Agarwal, and James F. George

8. Mast cells in kidney regeneration

Eric Douglas, Nicholas Charles, and Ulrich Blank

Section 3: Stem Cells in Regenerative Processes

9.Regeneration and replacement of endothelial cells and renal vascular repair

David P. Basile and Mervin C. Yoder

10. Stem cells in regenerative processes: Induced pluripotent stem cells

Kenji Osafune

11. Nephroprotective effect of urine-derived stem cells for renal injury

Yuanyuan Zhange and Anthony Atala

12. Amniotic stem cells and their exosomes

Jing Ji and Li Yang

13. Regenerative potential of stem-cell-derived extracellular vesicles

Hoon Young Choi and Hyeong Cheon Park

14. Stem cell therapies in diabetes

Sevim Kahraman, Danielle Diegisser, and Ercument Dirice

Section 4: Causes of Regenerative Failure

15. Progression of kidney disease as a maladaptive response to injury

Xuezhu Li, Fend Ding, Kyung Lee, and John Cijiang He

16. Molecular mechanisms of cellular senescence

Jamil Nehme, Marta Varela-Eirin, and Marco Demaria

17. Characteristics of senescent cells

Roland Schmitt and Anette Melk

18. Stress-induced senescence of tubular cells

David P. Baird, David A. Ferenbach, and Joseph V. Bonventre

19. Stress-induced senescence as a forme fruste of chronic kidney disease- A case for failed regeneration

Michael S. Goligorsky

20. Premature vascular aging and senescence in chronic kidney disease

Thomas Ebert and Peter Stenvinkel

21. Injury and regeneration in renal aging

Janka Babickova, Hai-Chun Yang, and Agnes B. Fogo

22. Gender-dependent mechanisms of injury and repair

Joel Neugarten and Ladan Golestaneh

Section 5: Kidney Engineering

23. Glomerular stem cells

Laura Lasagni, Benedetta Mazzinghi, and Paola Romagnani

24. Reconstitution of the kidney glomerular capillary wall

Titilola D. Kalejaiye, Jordan A. Holmes, Rohan Bhattacharya, and Samira Musah

25. Microfluidic modeling of glomerulus and tubular appartus

Gretchen J. Mahler and Stephanie Zhang

26. Matrix scaffolds in kidney engineering

Sean Muir, Catherine La Pointe, Domenica Ida Marino, Amish Asthana, and Guiseppe Orlando

Section 6: Emerging Clinical Aspects of Regenerative Therapy

27. Reprogramming toward kidney regeneration: New technologies and future promises

Yun Xia and Juan Carlos Izpisua Belmonte

28. Therapy cell reconditioning

Michael S. Goligorsky

29. Senomorphic, senolytic, and rejuvenation therapies

Xiang Yang Zhu and Lilach O. Lerman

30. Natural products in regeneration Rachel B. Wilson, Jason J. Lee, Geoffrey Pickering, and Nica M. Borradaile

31. Nanotargeting to the kidney

Ryan M. Williams, Chintan Kapadia, Edgar A. Jaimes, and Daniel A. Heller

32. Small molecules in regeneration

Amanda E. Crunk, Aneta Przepiorski, and Neil Hukriede

33. Systems biology in diagnosis and reamtnet of kidney disease

Jennifer Schaub and Matthias Kretzler

34. Overview of ethical concerns raised by kidney organoids

Paola Nicolas and Ira Bedzow

35. Manufacturing challenges and solutions for tissue engineering and regenerative medicine technologies

Joshua Hunsberger and Sita Somara

Erscheinungsdatum	21.06.2021
Verlagsort	San Diego
Sprache	englisch
Maße	216 x 276 mm
Gewicht	1630 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-12-823318-4 / 0128233184
ISBN-13	978-0-12-823318-4 / 9780128233184
Zustand	Neuware