Inflammation and Epilepsy: New Vistas

Damir Janigro, Astrid Nehlig, Nicola Marchi (Herausgeber)

Buch | Hardcover

VIII, 237 Seiten

2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-67402-1 (ISBN)

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This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.

lt;p>Damir Janigro

Department of Physiology and Biophysics

Case Western Reserve University

Cleveland

Ohio

USA

Astrid Nehlig

INSERM

Strasbourg

France

Nicola Marchi

Institut de Génomique Fonctionnelle

University of Montpellier

Montpellier

France

Pro and Anti-Inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium.- Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders.- Glial Mechanisms of Inflammation during Seizures.- Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy.- Blood T cells and Cytokine Levels during Interictal-Ictal Transitions.- Autoantibodies, Encephalopathies and Epilepsy.- Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline.- Ketogenic Diet, Inflammation and Epilepsy.- Role of Regulatory T cells in Epilepsy.- Inflammation at the Neurovascular Unit in Post-Traumatic Epilepsy.

Erscheinungsdatum	20.05.2021
Reihe/Serie	Progress in Inflammation Research
Zusatzinfo	VIII, 237 p. 1 illus.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	529 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Brain-body Axis • Cerebrovasculature • Epilepsy • Infectious Diseases • inflammatory mechanisms • Maternal and Perinatal Influences • microbiota • Neurological Diseases • therapeutic targets
ISBN-10	3-030-67402-9 / 3030674029
ISBN-13	978-3-030-67402-1 / 9783030674021
Zustand	Neuware