Protein Allostery in Drug Discovery
Springer Verlag, Singapore
978-981-13-8721-0 (ISBN)
Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA
Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Orthosteric Sites.- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators.- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands.- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network.- Chapter 10. GPCR Allosteric Modulator Discovery.- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs).- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins.- Chapter 15. Engineering Allostery into Proteins.
Erscheinungsdatum | 16.01.2021 |
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Reihe/Serie | Advances in Experimental Medicine and Biology ; 1163 |
Zusatzinfo | 82 Illustrations, color; 21 Illustrations, black and white; XII, 384 p. 103 illus., 82 illus. in color. |
Verlagsort | Singapore |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Medizin / Pharmazie ► Pharmazie |
Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Chemie ► Technische Chemie | |
Technik ► Medizintechnik | |
Technik ► Umwelttechnik / Biotechnologie | |
Schlagworte | Allosteric Drug Discovery • allosteric modulator • Allosteric regulation • Allosteric Site • Protein Allostery |
ISBN-10 | 981-13-8721-4 / 9811387214 |
ISBN-13 | 978-981-13-8721-0 / 9789811387210 |
Zustand | Neuware |
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