Retinal and Choroidal Vascular Changes and Systemic Diseases in Rats

Corrosion Cast and Scanning Electron Microscopy

T. Amemiya (Autor)

Buch | Hardcover

80 Seiten

2003
Springer Verlag, Japan
978-4-431-00612-1 (ISBN)

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Retinal and choroidal vasculatures are easily affected by various systemic diseases, and changes in the retina can easily be observed with various procedures such as direct and indirect ophthalmoscopy, scanning laser ophthalmoscopy, fluorescein fundus angiography, and indocyanin green fundus angiography. Vascular changes are the major, most prominent, and most important fundus changes. The above-mentioned procedures can reveal vascular changes clearly, but mainly reveal changes in the superficial layer of the retina. In addition, these procedures cannot show the three-dimensional architecture of the retina. Usually we can barely obtain the view of that three dimensional architecture. At the same time, pathological findings are well described, but most of them are based on histological and cytological methods. Thus, three-dimensional description of pathology is rare. Vascular corrosion cast scanning electron microscopy can provide a very useful three-dimensional view of the microvasculature and can demonstrate the fine structural architecture of the capillary network. However, the application of this method to the retinal and choroidal vasculature is very difficult, especially in small eyes. We succeeded in making good corrosion casts of retinal and choroidal vessels in the rat. Using this method during the past 10 years we have examined the retinal and choroidal vascular architecture of rats with various systemic diseases such as aging, hypertension, diabetes mellitus, and arteriosclerosis.

I. The Retinal Vasculature.- 1. Materials and Methods.- 2. Normal Retinal Vasculature.- 3. Retinal Vascular Changes During Aging.- 4. Vascular Changes in Retinas of Spontaneously Hypertensive Rats.- 5. Retinal Vascular Changes in Arteriosclerosis.- 6. Retinal Vascular Changes in Diabetes Mellitus.- References.- II. The Choroidal Vasculature.- 1. Microvascular Architecture of the Normal Rat Choroid.- 2. Aging.- 3. Hypercholesterolemia.- 4. Hypertension.- 5. Microvascular Architecture of Spontaneously Diabetic Rats.- References.

Erscheint lt. Verlag	23.4.2003
Zusatzinfo	VIII, 80 p.
Verlagsort	Tokyo
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Augenheilkunde
ISBN-10	4-431-00612-5 / 4431006125
ISBN-13	978-4-431-00612-1 / 9784431006121
Zustand	Neuware