Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy

A Handbook for Diagnosis and Management

Maria E. Suarez-Almazor, Leonard H. Calabrese (Herausgeber)

Buch | Softcover

XIV, 363 Seiten

2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-56823-8 (ISBN)

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With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease.

This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology, immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk-benefit ratios when managing patients with rheumatic irAE.

Cancer Immunotherapy-induced Rheumatic Syndromes is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.

Maria E. Suarez-Almazor, MD, PhD. Barnts Family Professor Departments of Health Services Research and General Internal Medicine, Section of Rheumatology and Clinical Immunology The University of Texas MD Anderson Cancer Center FCT 9.5026 1400 Pressler St (Unit 1444) Houston, TX, 77030 msalmazor@mdanderson.org Leonard H. Calabrese, D.O. Professor of Medicine, Cleveland Clinic Lerner College of Medicine RJ Fasenmyer Chair of Clinical Immunology Vice Chairman, Department of Rheumatic and Immunologic Diseases College of Medicine of Case Western Reserve University 9500 Euclid Avenue, Desk A50 Cleveland, Ohio 44195 CALABRL@ccf.org

PART 1 - INTRODUCTION.- 1. Cancer Immunology and the evolution of immunotherapy.- 2. Cancer immunotherapy: overview.- 3. Pathogenesis of immune-related adverse events.- PART 2 – IMMUNE-RELATED ADVERSE EVENTS WITH IMMUNE-CHECKPOINT INHIBITORS.- 4. Arthritis.- 5. Polymyalgia rheumatica.- 6. Myositis.- 7. Sicca syndromes.- 8. Sarcoidosis.- 9. Miscellaneous rheumatic syndromes.- 10. Non-rheumatic immune-related adverse events.- 11. Immune-related adverse events with other cancer immunotherapies.- PART 3 – CANCER IMMUNOTHERAPY IN PATIENTS WITH PRE-EXISTING RHEUMATIC DISEASES.- 12. Inflammatory arthritis.- 13. Other rheumatic autoimmune diseases.- 14. Choosing the right therapy.- 15. Risk-benefit considerations.- 16. Patient education and shared-decision making.

Erscheinungsdatum	01.03.2021
Zusatzinfo	XIV, 363 p. 19 illus., 16 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	127 x 203 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Cancer immunotherapy and arthritis • Cancer immunotherapy and myositis • Cancer immunotherapy and polymyalgia rheumatic • Cancer immunotherapy and rheumatic diseases • Cancer immunotherapy and Sjogren’s syndrome • Cancer immunotherapy-induced rheumatic diseases • Immune checkpoint inhibitors (ICI) • Rheumatic immune-related adverse events (irAE)
ISBN-10	3-030-56823-7 / 3030568237
ISBN-13	978-3-030-56823-8 / 9783030568238
Zustand	Neuware