Myelodysplastic Syndrome

From Diagnosis to Treatment

Buch | Hardcover

377 Seiten

2020
Nova Science Publishers Inc (Verlag)
978-1-5361-7997-2 (ISBN)

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In this compilation, the authors review the biological aspects of myelodysplastic syndrome disease, diagnosis, and treatment, as well as innovations involving genetics and new treatment perspectives. Myelodysplastic syndromes are a heterogeneous group of clonal haematopoietic stem cells disorders characterized by dysplasia, as well as peripheral blood cytopenias with a hypercellular marrow and ineffective hematopoiesis. Myelodysplastic syndromes are frequently associated with acute and chronic inflammation, and autoimmune disorders such as: rheumatoid arthritis, bowel disease, diverse types of vasculitis, autoimmune anemias, several rheumatic and skin disorders, and certain thyroid disorders. Spliceosome mutations are the most frequent mutations found in blood and bone marrow cells of myelodysplastic syndromes patients. As such, the authors explore the four predominant splicing factor genes: SF3B1, SFRS2, U2AF1, ZRSR2. Subsequently, this collection discusses the CSNK1A1 gene in the context of myelodysplastic syndromes. It is located at 5q32 within the deleted region, which encodes for casein kinase 1Î± (CK1Î±). CK1Î± is a component of a multiprotein Î²-catenin destruction complex that regulates Wnt/Î²-catenin and p53 pathways. The concluding study focuses on the mutations in epigenetic modifiers occur which myelodysplastic syndromes and drive this disease, such as: DNA methylation, histone acetylation, and RNA interference that alters gene expression.

Preface; Myelodysplastic Syndrome: An Overview; An Updated Approach to Myelodysplastic Syndromes (MDS); The Inflammatory and Autoimmune Dysregulation in Myelodysplastic Syndromes; Spliceosome Mutations and Alternative Splicing of Pre-Messenger RNA in Myelodysplastic Syndromes; Myelodysplastic Syndrome with Chromosome 5q: Deletion and Its Treatment; Epigenetic Mechanisms and Therapy of Myelodysplastic Syndromes; Index.

Erscheinungsdatum	30.07.2020
Sprache	englisch
Gewicht	642 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
ISBN-10	1-5361-7997-3 / 1536179973
ISBN-13	978-1-5361-7997-2 / 9781536179972
Zustand	Neuware