Protein Degradation with New Chemical Modalities
Royal Society of Chemistry (Verlag)
978-1-78801-686-5 (ISBN)
PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?;
Structural and Biophysical Principles of Degrader Ternary Complexes;
Immediate and Selective Control of Protein Abundance using the dTAG System;
Developing Pharmacokinetic/Pharmacodynamic Relationships with PROTACs;
New Activities of CELMoDs, Cereblon E3 Ligase Modulating Drugs;
Structure-based PROTACs Design;
Plate-Based High Throughput Cellular Degradation Assays to Identify PROTACS Molecules and Protein Degraders;
PROTAC Targeting BTK for the Treatment of Ibrutinib-Resistant B-Cell Malignancies;
An Efficient Approach Toward Drugging Undruggable Targets;
E3-Mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes;
Plant E3 Ligases as Versatile Tools for Novel Drug Development and Plant Bioengineering;
Deubiquitinase Inhibitors: An Emerging Therapeutic Class;
Targeting Translation Regulation for the Development of Novel Drugs;
Classes, Modes-of-action and Selection of New Modalities in Drug Discovery;
Small Molecule Targeted Degradation of RNA
Erscheinungsdatum | 11.03.2020 |
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Reihe/Serie | Drug Discovery ; Volume 74 |
Verlagsort | Cambridge |
Sprache | englisch |
Maße | 156 x 234 mm |
Gewicht | 733 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Naturwissenschaften ► Biologie ► Biochemie | |
ISBN-10 | 1-78801-686-6 / 1788016866 |
ISBN-13 | 978-1-78801-686-5 / 9781788016865 |
Zustand | Neuware |
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