Regucalcin

Metabolic Regulation and Disease

Buch | Softcover

174 Seiten

2019
Nova Science Publishers Inc (Verlag)
978-1-5361-6172-4 (ISBN)

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This book, which is entitled "Regucalcin: Metabolic Regulation and Disease", introduces the recent topics regarding the involvement of regucalcin in metabolic regulation and its related diseases. Cell signaling system may be potent interest in the fields of biomedical research. Regucalcin, which was discovered as a calcium-binding protein in 1978, is demonstrated to play a potential role as a suppressor in manifold intracellular signaling process linked to transcription activity. With growing studies, regucalcin has been demonstrated to play a multifunctional role in the regulation of the function of various types of cells and tissues, including the regulation of intracellular calcium homeostasis, various enzymes activity, cell signal transduction, nuclear function and gene expression, cell proliferation, apoptosis, and other cellular events. Regucalcin plays a pivotal role in maintaining cell homeostasis and protecting from disorders with ageing. This book focuses recent highlighted information regarding the role of regucalcin in metabolic regulation and its related diseases with aging. This book is constituted of 6 chapters as described in the following. This book will be of interest to graduate students, researchers, scientists and physicians focused on the fields of molecular and cellular biology, biomedical sciences, and clinical challenges.

Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.

PrefaceStructure of Regucalcin Gene and ProteinThe Horizons of Regucalcin in Male ReproductionRegucalcin: A Tumor-Associated Antigen and a Tumor-Suppressing MoleculeThe Role of Regucalcin in Bone Remodeling and OsteoporosisInvolvement of Regucalcin in Diabetes and HyperlipedemiaExtracellular Vesicles: A Conversation in the BodyIndex.

Erscheinungsdatum	05.12.2019
Verlagsort	New York
Sprache	englisch
Maße	152 x 229 mm
Gewicht	266 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
ISBN-10	1-5361-6172-1 / 1536161721
ISBN-13	978-1-5361-6172-4 / 9781536161724
Zustand	Neuware