Protein Allostery in Drug Discovery (eBook)
XII, 384 Seiten
Springer Singapore (Verlag)
978-981-13-8719-7 (ISBN)
The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA
The book focuses on protein allostery in drug discovery. Allosteric regulation, 'the second secret of life', fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
| Erscheint lt. Verlag | 9.11.2019 |
|---|---|
| Reihe/Serie | Advances in Experimental Medicine and Biology | Advances in Experimental Medicine and Biology |
| Zusatzinfo | XII, 384 p. 103 illus., 82 illus. in color. |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Pflege |
| Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Chemie | |
| Technik ► Medizintechnik | |
| Schlagworte | Allosteric Drug Discovery • allosteric modulator • Allosteric regulation • Allosteric Site • Protein Allostery • Protein Structure |
| ISBN-10 | 981-13-8719-2 / 9811387192 |
| ISBN-13 | 978-981-13-8719-7 / 9789811387197 |
| Haben Sie eine Frage zum Produkt? |
PDF (Wasserzeichen)Größe: 11,4 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich
