Ocular Oncology

Daniel M. Albert, Arthur Polans (Herausgeber)

Buch | Softcover

526 Seiten

2019
CRC Press (Verlag)
978-0-367-44667-3 (ISBN)

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This book focuses on uveal melanoma and retinoblastoma, the principal tumors originating in the eyes of adults and children, respectively. It discusses the current status of clinical trials in ocular oncology and provides a review of risk and prognostic factors associated with eye tumors.

Survival rates in cases of uveal melanoma and retinoblastoma - the leading intraocular malignancies in adults and children - may be high, but means of earlier diagnosis and improved treatment options are needed to preserve vision and prevent metastasis. This reference deals principally with the molecular biology and genetic factors which trigger and promote the two most common ocular tumours.

Daniel M. Albert, Arthur Polans

1. Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye 2. Clinical Overview: Retinoblastoma 3. Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements 4. Epidemiology of Retinoblastoma 5. Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis 6. Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma 7. A Cascade of Genomic Changes Leads to Retinoblastoma 8. The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma 9. Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells in Vitro 10. p53 and the Molecular Regulation of Cell Fate in Retinoblastoma 11. Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy 12. Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy 13. Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma 14. Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues 15. Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment 16. The Treatment of Retinoblastoma 17. Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors 18. Clinical Trials in Retinoblastoma 19. Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis 20. Retinoblastoma: Pathology and Prognosis 21. Molecular Genetics of Retinoblastoma 22. Genetically Engineered Mouse Models of Retinoblastoma 23. Treatment of Extraocular Retinoblastoma

Erscheinungsdatum	05.12.2019
Verlagsort	London
Sprache	englisch
Maße	174 x 246 mm
Gewicht	975 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Augenheilkunde
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
ISBN-10	0-367-44667-7 / 0367446677
ISBN-13	978-0-367-44667-3 / 9780367446673
Zustand	Neuware