Concepts and Principles of Pharmacology

100 Years of the Handbook of Experimental Pharmacology

James E. Barrett, Clive P. Page, Martin C. Michel (Herausgeber)

Buch | Hardcover

VIII, 466 Seiten

2020 | 1st ed. 2019
Springer International Publishing (Verlag)
978-3-030-35361-2 (ISBN)

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Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Part 1. A Century of Advances in Pharmacology.- 1. Perspectives of Pharmacology Over the Past 100 years.- 2. Emergent concepts of receptor pharmacology.- 3. The Evolving Landscape of Cancer Therapeutics.- 4. Monoclonal Antibodies: Past, Present and Future.- 5. 100 years of Drug Delivery to the Lungs.- 6. Exploiting the Diversity of Ion Channels: Ion channel Pharmacology for Pain modulation.- 7. Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications.- Part 2. Recent developments and enabling technologies in pharmacology.- 8. Genetically Encoded Fluorescent Calcium and Voltage Indicators.- 9. Mechanistic Image-Based Modeling: Concepts and Applications of Image-Based Modeling.- 10. Pharmacometabonomics: The Prediction of Drug Effects Using Metabolic Profiling.- 11. The Microbiome and its Potential for Pharmacology.- 12. Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.- Part 3. The future of pharmacology.- 13. The future of clinical trial design: The Transition from Hard Endpoints to Value-Based Endpoings.- 14. Placebos and the Placebo Effect in Drug Trials.- 15. Pharmacoepidemiology.- 16. Why are new drugs expensive and how can they stay affordable?

Erscheinungsdatum	22.01.2020
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	VIII, 466 p. 100 illus., 30 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	875 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	Allosteric Modulation • biased agonism • Drug Delivery • History • Immunopharmacology • Ion channel • Metabolomics • microbiome • monoclonal antibodies • Natural Products • Nobel prize • Optogenetics • Organ on a chip • Pharmacogenomics • Placebo • siRNA • Trial design
ISBN-10	3-030-35361-3 / 3030353613
ISBN-13	978-3-030-35361-2 / 9783030353612
Zustand	Neuware