HIV-1 Latency
Springer International Publishing (Verlag)
978-3-030-13214-9 (ISBN)
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
Guido Silvestri Emory University School of Medicine, Atlanta, GA 30329, USA gsilves@emory.edu Mathias Lichterfeld The Brigham and Women's Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA MLICHTERFELD@mgh.harvard.edu
Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure.
| Erscheinungsdatum | 08.11.2019 |
|---|---|
| Reihe/Serie | Current Topics in Microbiology and Immunology |
| Zusatzinfo | VII, 248 p. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 397 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin |
| Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Schlagworte | antiretroviral therapy • antiviral immune response • Cd4+ T cell subsets • HIV eradication • latency reactivation • virus reservoirs |
| ISBN-10 | 3-030-13214-5 / 3030132145 |
| ISBN-13 | 978-3-030-13214-9 / 9783030132149 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
