Osteoarthritis
Oxford University Press (Verlag)
978-0-19-850967-7 (ISBN)
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At a time when prevalance of osteoarthritis (failure of the joint) is increasing with an aging population it is timely to review the latest evidence and management strategies for optimal treatment of patients with this, the most common joint disease of mankind. A number of exciting new developments related to etiopathogenesis and management make it highly desirable at this time to publish a fully comprehensive authorative discussion of the risk factors, mechanisms of joint damage, clinical aspects, differential diagnosis and treatment of OA. A review of the current understanding of the management of this disorder and of the basic mechanisms involved provides the rationale for publication of this new fully-updated edition. The book looks at the mechanisms for joint failure and how this may be due to abnormal cartilage or disease in underlying tissue. Significant coverage is given to exciting new evidence on disease-modifying drugs and methodologies for their outcomes evaluation. It is becoming increasingly recognised that optimal management of osteoarthritis requires a comprehensive program involving drugs and nonmedicinal components and, in some cases, surgery.
Chapters on both non-surgical and surgical therapy are contained in the management section. The full coverage given in this book allows the physician to consider and choose the right blend of treatment for each patient from the range available whether physical, pharmacologic, surgical or supportive. The book is sympathetic to the significant differences that often exist between the perception of the patient and that of the physician regarding what's important in treatment and coverage is therefore given to the outcome measures needed for optimal evaluation of both. Highly illustrated in full colour throughout this difinative text is written principally for the clinical rheumatologists, although primary care physicians, orthopaedic surgeons, allied health professionals, basic researchers, members of the pharmaceutical industry who are involved in drug research and development, and regulatory staff also should find it useful.
1. Definition and classification of osteoarthritis ; 2. Epidemiology of osteoarthritis ; 3. The economics of osteoarthritis ; 4.1 EVIDENCE FOR THE INHERITANCE OF OSTEOARTHRITIS ; 4.2 Specific gene defects associated with osteoarthritis ; 4.3 Laboratory approaches to the identification of genetic association in osteoarthritis ; 5. Pathology of osteoarthritis ; 6. Paleopathology of osteoarthritis ; 7.1 INTRODUCTION: THE CONCEPT OF OSTEOARTHRITIS AS FAILURE OF THE DIARTHRODIAL JOINT ; 7.2 PATHOGENESIS OF STRUCTURAL CHANGES IN THE OSTEOARTHRITIC JOINT ; 7.2.1.1 BIOCHEMISTRY AND METABOLISM OF NORMAL AND OSTEOARTHRITIC CARTILAGE ; 7.2.1.2 Proteolytic degradation of normal and osteoarthritic cartilage matrix ; 7.2.1.3 Articular cartilage repair ; 7.2.1.4 Mechanical properties of normal and osteoarthritic articular cartilage, and the mechanobiology of chondrocytes ; 7.2.1.5 Response of the chondrocyte to mechanical stimuli ; 7.2.1.6 Crystals and osteoarthritis ; 7.2.2.1 SUBCHONDRAL BONE IN THE PATHOGENESIS OF OSTEOARTHRITIS. MECHANICAL ASPECTS ; 7.2.2.2 Subchondral bone in the pathogenesis of osteoarthritis. Biological effects ; 7.2.2.3 Systemic changes in bone in osteoarthritis ; 7.2.3.1 SYNOVIAL MEDIATORS OF CARTILAGE DAMAGE AND REPAIR IN OSTEOARTHRITIS ; 7.2.3.2 Synovial physiology in the context of osteoarthritis ; 7.2.4.1 INNERVATION OF THE JOINT AND ITS ROLE IN OSTEOARTHRITIS ; 7.2.4.2 Neuromuscular Protective Mechanisms ; 7.2.4.3 Proprioception in Osteoarthritis ; 7.2.5 Local mechanical factors in the natural history of knee osteoarthritis, malignment and joint laxity ; 7.3.1 PERIPHERAL AND CENTRAL PAIN MECHANISMS IN OSTEOARTHRITIS ; 7.3.2 Why does the patient with osteoarthritis hurt? ; 8.1 SIGNS, SYMPTOMS, AND LABORATORY TESTS ; 8.2 Plain radiographic features of osteoarthritis ; 8.3 The natural history and prognosis of osteoarthritis ; 9.1 INTRODUCTION: THE COMPREHENSIVE APPROACH ; 9.2 Systemic analgesics ; 9.3 The role of NSAIDs in the treatment of Osteoarthritis ; 9.4 Economic considerations in pharmacologic management of osteoarthritis ; 9.5 Topical NSAIDs ; 9.6 Topical capsaicin cream ; 9.7 Intra-articular glucocorticoids and other injection therapies ; 9.8 Intra-articular hyaluronan injection ; 9.9 Nutritional therapies ; 9.10 Mechanisms by which micronutrients may influence osteoarthritis ; 9.11.1 EXERCISE FOR PATIENT WITH OSTEOARTHRITIS ; 9.11.2 Other Physical Therapies ; 9.11.3 Other Physical Therapies ; 9.12 Occupational therapy for the patient with Osteoarthritis ; 9.13 Patient education ; 9.14 Social support ; 9.15 Depression in osteoarthritis ; 9.16 Coping strategies for the patient with osteoarthritis ; 9.17 Irrigation of the osteoarthritic joint ; 9.18 Surgical approaches to preserving and restoring articular cartilage ; 9.19 Arthroplasty and its complications ; 9.20 Weight loss and Osteoarthritis ; 9.21 Patient adherence ; 10. Outcome assessment in osteoarthritis: a guide for research and clinical practice ; 11.1 INTRODUCTION ; 11.2.1 THE BIOLOGICAL PERSPECTIVES ; 11.2.2 The clinical perspective ; 11.3 Advantages and limitations of animal models in the discovery and evaluation of novel disease-modifying osteoarthritis drugs (DMOADS) ; 11.4.1 RADIOGRAPHIC GRADING SYSTEMS ; 11.4.2 Quantitation of radiographic changes ; 11.4.3 Magnetic resonance imaging ; 11.4.4 Arthroscopic evaluation of knee articular cartilage ; 11.4.5 Bone Scintigraphy ; 11.4.6 Ultrasonography ; 11.4.7 Defining and validating the clinical role of molecular markers in osteoarthritis ; 12. Design of clinical trials for evaluation of structure modifying drugs and new agents for symptomatic treatment of osteoarthritis
| Erscheint lt. Verlag | 7.8.2003 |
|---|---|
| Zusatzinfo | 171 full colour halftones and 118 line drawdings |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 228 x 284 mm |
| Gewicht | 1695 g |
| Themenwelt | Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie |
| Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie | |
| ISBN-10 | 0-19-850967-7 / 0198509677 |
| ISBN-13 | 978-0-19-850967-7 / 9780198509677 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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