Histopathology of Preclinical Toxicity Studies

Interpretation and Relevance in Drug Safety Evaluation

P. Greaves (Autor)

Buch | Hardcover

836 Seiten

1990
Elsevier Science Ltd (Verlag)
978-0-444-81311-4 (ISBN)

Infos

Histopathological assessment of tissue sections is an important componant of many preclinical studies which are conducted to support the safety and clinical development of novel therapeutic agents for use in the treatment of human diseases. The drug discovery process, aided by modern biotechnology, is now capable of generating highly potent, pharmacologically active agents which can give rise to quite unusual constellations of tissue pathology. The complexity and the number of histopathological findings in individual studies indicate the need for lucididy in descriptions and conclusions. In the light of these and other difficulties, this text is aimed towards bringing together into one volume a description of histopathological changes which relate to toxicity testing of therapeutic agents in the usual test species: rat, mouse, dog and non-human primate. This book is an excellent starting point for the analysis of drug-induced findings in toxicity studies.

Inhalt

Preface. Acknowledgements. I. Integumentary System. Skin/subcutaneous tissue. II. Mammary Gland. III. Haemopoietic and Lymphatic Systems. Bone marrow/blood. Lymphoid system. Spleen. Lymph nodes. Thymus. Lymphoreticular neoplasms. IV. Musculoskeletal System. Bone. Muscle (striated or skeletal). V. Respiratory Tract. Nose, nasal sinuses, nasopharynx. Larynx and trachea. Bronchi/lungs. VI. Cardiovascular System. Heart and pericardium. Systemic blood vessels. Pulmonary blood vessels. VII. Digestive System 1. Mouth and oropharynx. Salivary glands. Oesophagus. Forestomach. Stomach (glandular). Small intestine (duodenum, jejunum, ileum). Large intestine (caecum, colon, rectum). VIII. Digestive System 2. Liver. Bile ducts, biliary system. Exocrine pancreas. IX. Urinary Tract. Kidney. Urinary bladder. X. Male Genital Tract. Prostate gland. Epididymis. Testis. XI. Female Genital Tract. Vagina. Cervix. Uterus. Ovary. XII. Endocrine Glands. Pituitary gland. Adrenal gland. Thyroid gland. Parathyroid gland. XIII. Nervous System and Special Sense Organs. Brain. Spinal cord, peripheral nerve, spinal nerve roots. Eye. Ear. Subject Index.

Produkt-Details

• Erscheint lt. Verlag: 17.12.1990
• Verlagsort: Oxford
• Sprache: englisch
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 0-444-81311-X / 044481311X
• ISBN-13: 978-0-444-81311-4 / 9780444813114
• Zustand: Neuware