Haploidentical Transplantation

Concepts & Clinical Application

Stefan O. Ciurea, Rupert Handgretinger (Herausgeber)

Buch | Softcover

XI, 337 Seiten

2019 | 1. Softcover reprint of the original 1st ed. 2018
Springer International Publishing (Verlag)
978-3-030-09611-3 (ISBN)

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In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.

Stefan Ciurea is Associate Professor in the Department of Stem Cell Transplantation and Cellular Therapy at the University of Texas MD Anderson Cancer Center and leader of the Haploidentical Transplant Program at this institution. Dr. Ciurea received his medical degree from the Gr. T Popa University of Medicine and Pharmacy Iasi, Romania, and had Internal Medicine training at Harrisburg Hospital/PennState University, Fellowship in Hematology/Oncology at the University of Illinois at Chicago and Fellowship in Hematopoietic Stem Cell Transplantation and the University of Texas MD Anderson Cancer Center. He developed a Haploidentical Transplant Program at this institution with the goal to expand safe transplantation to all patients in need. Dr. Ciurea has made significant contributions in this field, primarily in identifying HLA antibodies as major cause of graft failure in mismatched transplantation and improving outcomes for patients with myeloid malignancies treated with hapl oidentical transplantation, and is principal investigator on multiple clinical trials.

Historical perspective and current trends in haploidentical transplantion.- Part 1: Graft manipulation and methods to control T-cell alloreactivity. -Positive CD34+ cell selection.- Selective allo-depletion: beta and CD19+ cell T cell depletion.- T cell addback in T- cell depleted haploidentical transplant.- Hematopoietic myeloid growth factor primed bone marrow and peripheral blood hematopoietic progenitor cells.- Photodepletion of allo-reactive T cells.- Post-transplant cyclophosphamide in haploidentical transplant.- Part 2: Ideal graft & donor.- Graft source: Marrow versus peripheral blood with PTCy- Does it matter?.- Anti-HLA antibodies: Assessment and mitigating strategies.- Selection of haploidentical donors: What is the art?.- Myeloablative versus non-myeloablative conditioning regimen- Does it matter and how best to select?.- Part 3: Disease-specific pediatric population.- Nonmalignant diseases in children.-

en.-="" part="" 4:="" disease-specific="" adult="" population.-="" non-malignant="" adults.-="" acute="" myelogenous="" leukemia="" lymphomas-="" parameswaran="" hari.-="" chronic="" leukemias="" and="" myeloproliferative="" neoplasms.-="" immunologic="" reconstitution="" after="" haploidentical="" transplantation.-="" prevention="" treatment="" of="" relapse="" transplant.-="" unique="" complications="" limitations="" future="" prospects="" transplantation

Erscheinungsdatum	05.03.2022
Reihe/Serie	Advances and Controversies in Hematopoietic Transplantation and Cell Therapy
Zusatzinfo	XI, 337 p. 25 illus., 18 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	726 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Schlagworte	Haploidentical Transplantation • Immunologic Reconstitution • Myeloablative Conditioning Regimen • Non-Myeloablative Condtioning Regimen • T-Cell Alloreactivity
ISBN-10	3-030-09611-4 / 3030096114
ISBN-13	978-3-030-09611-3 / 9783030096113
Zustand	Neuware