In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

Toru Takebayashi, Robert Landsiedel, Masashi Gamo (Herausgeber)

Buch | Hardcover

223 Seiten

2019 | 1st ed. 2019
Springer Verlag, Singapore
978-981-13-8432-5 (ISBN)

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This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials.

With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.

Toru Takebayashi Keio University Graduate School of Health Management Fujisawa, Kanagawa, Japan Robert Landsiedel BASF SE Experimental Toxicology and Ecology Ludwigshafen am Rhein, Germany Masashi Gamo National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba, Ibaraki, Japan

1 The role of in vivo screening studies in assessing manufactured nanomaterials.- Part 1 Short Term Inhalation Study.- 2. The short-term inhalation study (STIS) as a range finder and screening tool in a tiered grouping strategy.- 3. Use of short-term inhalation study to obtain initial hazard data and prepare for subacute and subchronic inhalation studies, and toxicokinetic studies.- 4. Subchronic inhalation Toxicity Study with a Vapor Grown Carbon Nanofiber in Male and Female Rats (OECD 413) – Does nanofiber exposure have adverse impacts on the cardiovascular system?.- Part 2 Intratracheal Administration Study.- 5. Comparison of responses in rat lung following inhalation and intratracheal administration of nanoparticles.- 6. Standardization of intratracheal instillation study of manufactured nanomaterials.- 7. Sample preparation and the chracterization for Intratracheal Administration.- 8. Development of intra-tracheal intra-pulmonary spraying (TIPS) as an alternative assay method for testing chronic toxicity and carcinogenic potential of multiwall carbon nanotubes.- 9. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study using Intratracheal Administration.- 10. Toxicokinetics of nano materials after the intratracheal administration.- 11. In Vitro Alveolar Epithelial Models toward the Prediction of Cytotoxicity Tests and Translocation Studies of Nanoparticles.

Erscheinungsdatum	06.09.2019
Reihe/Serie	Current Topics in Environmental Health and Preventive Medicine
Zusatzinfo	62 Illustrations, color; 8 Illustrations, black and white; VI, 223 p. 70 illus., 62 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Gesundheitswesen
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
Schlagworte	Hazard Evaluation • Initial Hazard Data • Intratracheal Administration • Pulmonary Bioassay • Short-Term Inhalation Study • STIs
ISBN-10	981-13-8432-0 / 9811384320
ISBN-13	978-981-13-8432-5 / 9789811384325
Zustand	Neuware