Pathogenesis of Idiopathic Scoliosis

Masafumi Machida, Stuart L. Weinstein, Jean Dubousset (Herausgeber)

Buch | Softcover

188 Seiten

2019 | Softcover reprint of the original 1st ed. 2018
Springer Verlag, Japan
978-4-431-56861-2 (ISBN)

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This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed forIS and an introduction to the directions in which research is heading to determine the primary cause of IS.

Masafumi Machida, M.D.: Director of National Institute of Musculo-Skeletal Disorders Stuart L. Weinstein,M.D.:Ignacio V. Ponseti Chair of Ortopaedic Surgery, Department of Orthopaedic Surgery University of Iowa Health Cara Jean Dubousset,M.D.: Academie Nationale de Medecine

1. Definition of Adolescent Idiopathic Scoliosis.- 2. Adolescent Idiopathic Scoliosis: Natural History.- 3.The Genetic Architecture of Adolescent Idiopathic Scoliosis.- 4. Biomechanics of Adolescent Idiopathic Scoliosis.- 5. Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers.- 6. Bone Metabolism in AIS.- 7. Neurological Research in Idiopathic Scoliosis.

Erscheinungsdatum	04.03.2022
Zusatzinfo	21 Illustrations, color; 17 Illustrations, black and white; IX, 188 p. 38 illus., 21 illus. in color.
Verlagsort	Tokyo
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
Schlagworte	central nervous system • Genetics research • Idiopathic scoliosis • Pathogenesis Study • spinal deformity
ISBN-10	4-431-56861-1 / 4431568611
ISBN-13	978-4-431-56861-2 / 9784431568612
Zustand	Neuware