Development of the Cerebellum from Molecular Aspects to Diseases

Buch | Softcover

IX, 505 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-86693-2 (ISBN)

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The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.

Dr. Hassan Marzban (Editor) is a human anatomist and cerebellar developmental biologist, at Department of Human Anatomy and Cell Sciences, the College of Medicine, Faculty of Health Sciences, University of Manitoba. Dr. Marzban is a pioneer in the field and his research is focused to understand the cellular and molecular mechanisms of the developing cerebellum and neurodevelopmental disorders and disabilities.

Chapter1. The development of the cerebellum: from the beginnings.- Part I: Responsibilities and liabilities.- Chapter2. The embryology and anatomy of the cerebellum.- Chapter 3. Cellular and genetic programs underlying cerebellum development.- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. Chapter5. Cerebellar developmental disorders and cerebellar nuclei.- Chapter6. Motor circuit abnormalities during cerebellar development.- Chapter7. Developmental disorders of the cerebellum and neurotrophic factors.- Chapter8. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development.- Chapter9. The ubiquitin proteasome system and cerebellar developmental disease.- Chapter10. Epigenetics and Cerebellar Neurodevelopmental Disorders.- Chapter11. Hormonal regulation of cerebellar development and its disorders.- Chapter12. Infections of the Cerebellum.- Chapter13. Neuroimmune mechanisms of cerebellar development and its developmental disorders.- Chapter14. Teratogenic influences on cerebellar development.- Chapter15. Primary pediatric brain tumors of the posterior fossa.- Chapter16. Primary pediatric brain tumors of the posterior fossa.- Chapter17. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa.- Chapter18. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder.- Chapter19. Congenital cerebellar disease.- Chapter20. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders.- Chapter21. Epidemiologyof cerebellar disorders.- Chapter22. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum.

Erscheint lt. Verlag	12.8.2018
Reihe/Serie	Contemporary Clinical Neuroscience
Zusatzinfo	IX, 505 p. 97 illus., 70 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	783 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	cerebellar growth and development • cerebellum • Diagnosis • Management • Neurological disorder
ISBN-10	3-319-86693-1 / 3319866931
ISBN-13	978-3-319-86693-2 / 9783319866932
Zustand	Neuware