Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

The Shape of Organic Synthesis to Come

Buch | Hardcover

355 Seiten

2019 | 1st ed. 2019
Springer Verlag, Singapore
978-981-13-6243-9 (ISBN)

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This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology.

1. Microbial Fraction Library: A Screening Source for Drug Discovery.- 2. Efficient Total Synthesis of Ōmura Natural Products.- 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol.- 4. Synthetic Approaches on the Pluramycin-class Antibiotics.- 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II.- 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis.- 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications.- 8. Total Synthesis of Ingenol.- 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids.- 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid.- 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds.- 12. Exploring bioactive marine natural products and identification of their molecular targets.- 13. Target protein chemical modification.- 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes

Erscheinungsdatum	25.06.2019
Zusatzinfo	127 Illustrations, color; 279 Illustrations, black and white; XXV, 355 p. 406 illus., 127 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Cutting-edge organic synthesis • Fatty acid metabolites related to inflammation • Finding pharmaceutically promising compounds • Organic synthesis for chemical biology • Super-carbon chain compounds
ISBN-10	981-13-6243-2 / 9811362432
ISBN-13	978-981-13-6243-9 / 9789811362439
Zustand	Neuware