Progress in Immunology
Springer Berlin (Verlag)
978-3-642-83757-9 (ISBN)
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I Structure and Function of Recognition and Effector Molecules.- The T Cell Receptor Complex.- T Cell Receptors.- Positive and Negative Selection of T Cells: A Transgenic Model.- Selection of an ?? T Cell Antigen Receptor In Vivo and Engineering a Solulizable Form.- Mice Transgenic for the T Cell Receptor C?4 Gene are Altered in T Cell Development.- Lymphocytes Bearing Either ??-TCR or ??-TCR Can Recognize Non-MHC Encoded CD1 Molecules.- Assembly of the T Cell Receptor/CD3 Complex.- MHC and Antigen Presentation.- Structural and Functional Analysis of Human Class I and Class II Major Histocompatibility Complex Proteins, with Special Emphasis on Alloreactivity.- Further Analysis of the Role of MHC Molecules in Antigen Presentation.- Studies on the Nature of Physiologically Processed Antigen.- Role of MHC Polymorphism in Autoimmune Disease.- Complex Regulation of MHC Class I Expression: Constitutive and Modulated Patterns of Expression.- Somatic Changes of Ig and T Cell Receptor Genes.- Organization and Reorganization of Antigen Receptor Genes.- The Human Immunoglobulin Kappa Genes.- Somatic Changes in the Immune Response to the Hapten 2-Phenyl Oxazolone.- The Lymphoid V (D) J Recombination Activity: Studies of Exogenous Plasmid Substrates in Whole Cells.- Early Expression of Ig-Related Genes in the Human B-Cell Lineage.- Cell Interaction Molecules.- Adhesion Receptors Regulate Antigen-Specific Interactions, Localization, and Differentiation in the Immune System.- From Marker Antigens for T Lymphocyte Subsets to Molecules that Regulate Cell Activation.- The T-Cell Antigen Receptor and CD2 in Rat T-Cell Activation and Ontogeny.- Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies.- A Lymphocyte Homing Receptor: A Member of an Emerging Class of Cell Adhesion Molecules.- Complement.- to the Symposium on Complement.- The Regulators of Complement Activation (RCA) Gene Cluster.- Host Cell Protection from Complement by Glycosylphosphatidylinositol- Anchored Complement Inhibitors and Their Deficiencies in Paroxysmal Nocturnal Hemoglobinuria.- Inflammation-Promoting Complement Fragments.- Evasion Strategies of Microorganisms.- Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators.- Protein Phosphorylation as a Mechanism of Resistance Against Complement Damage.- The Mosaic Nature of the Complement Proteins.- II Cell Developments.- Development of T Cells.- 1. Phylogeny, Stem Cells, Lineages.- The Role of the Thymus in the Development of T-Cells.- Ontogeny of T Cells and a Third Lymphocyte Lineage in the Chicken.- Analysis of Hematopoietic Stem Cell Development In Vivo.- Utilization of a Bone Marrow Suspension Culture System for the Analysis and Manipulation of T-Cell Development.- Diversity, Development, Ligands and Probable Functions of ??T Cells.- Thymic Epithelial Cells Induce In Vitro Differentiation of PRO-T Lymphocyte Clones into TCR ?, ?/CD3+ and TCR ?,?/CD3+ Cells.- Expression of T Cell Receptor Associated Proteins During Human T Cell Development.- 2. Repertoire Selection.- Selection of the T Cell Repertoire in the Thymus.- T Cell Differentiation in Lower Vertebrates.- Participation of CD4 and CD8 Accessory Molecules in the Development and Selection of T Lymphocytes.- Development of the T Cell Repertoire: Contributions of Both TCR-MHC and Accessory Molecule-MHC Interactions.- Self-Nonself Discrimination by the Immune System.- Development of B Cells.- 1. Phytogeny, Stem Cells, Lineages.- Development and Regulation of the B Lymphocyte Lineage: An Interpretive Overview.- Control of Expression of Immunoglobulin Genes.- Regulation of Immunoglobulin Gene Rearrangement.- Isolation and Characterization of Hematopoietic Stem Cells and Progenitors.- Structure, Control of Expression and Putative Function of the PreB Cell- Specific Genes VpreB and ?5.- 2. Repertoire Selection.- B Cell Differentiation: Development of Antibody Repertoires.- Evolution of Immunoglobulin Gene Complexity.- Are Autoreactive B-Cells Deleted?.- Self-Tolerance in B Cells from Different Lines of Lysozyme Double-Transgenic Mice.- The Recombination Activating Gene and Lymphoid Differentiation.- Repertoire Selection in B Cell Subpopulations.- Memory.- Evolutionary and Somatic Immunological Memory.- Development of the B Cell Repertoire and the Ability to Respond to Bacteria Associated Antigens.- B Cell Lineages and Immunologic Memory.- The Influence of Somatic Mutation on Clonal Expansion.- Self-Nonself Discrimination by Precursors of Memory B Cells.- Identification of Human Naive and Memory T Cells.- Characterization of the Secondary Antibody Response Using Purified Memory B and T Cells.- The Production and Selection of Memory B Cells in Follicles.- Neoplastic Transformation of Lymphoid Cells and Myeloid Cells.- Tumors of Lymphoid and Myeloid Cells: Introduction.- The Ig/myc Translocation in Burkitt’s Lymphoma Is a Rate Limiting Step in Tumor Development with Multiple Phenotypic Consequences.- The Development of B-Lymphomas in the Chicken.- Bcl-2? Encodes a Novel Small Molecular Weight GTP Binding Protein.- Role of the Bcl-2 Proto-Oncogene in Neoplasia.- Transgenic Mice as Models for the Development of Haemopoietic Neoplasia.- Tumor Suppression in Somatic Cell Hybrids Between Burkitt’s Lymphoma Cells and EBV-Immortalized Lymphoblastoid Cells.- Primary Immunodeficiencies.- Primary Immunodeficiencies: Current Findings and Concepts.- X Chromosome Inactivation Analysis: A New Tool To Examine X-Linked Immunodeficiencies.- Nature of the Defect in the Scid Mouse Mutant.- The Wiskott-Aldrich Syndrome and CD43.- The Leukocyte Adhesion Deficiency.- Genotypic Studies of MHC Class III Genes in Individuals with IgA Deficiency and Common Variable Immunodeficiency.- Mapping of Two IgCH Gene Deletions in a Patient with IgG1 Deficiency.- III Effector Phases.- Cell Cooperation.- Cellular Cooperation in Antibody Production.- Clonal Deletion of Autoreactive T Lymphocytes: Insights from Neonatal Ontogeny.- Developmental Arrest of T Cell Receptor (TcR) Negative SCID Thymocytes and Release in the Presence of TcR+ Cells.- Costimulatory Interactions Determine Proliferation Versus Induction of Clonal Anergy During Type I CD4+ T-Cell Stimulation.- Signal Requirements for the Primary Activation of Murine CD8 T Lymphocytes.- Contact with Helper T Cells Does Not Limit the Induction of Resting B Cell Differentiation.- Clonal Expansion and Differentiation to Effector Function in Normal CD4 T Cell Subpopulations.- Cytokines and Their Receptors.- Structure and Function of Lymphokines and Their Receptors.- Heterogeneity of Mouse Helper T Cells and Cross-Regulation of TH1 and TH2 Clones.- Interleukin 2 Receptor Targeted Immunotherapy — Update and an Attempt at Synthesis.- Molecular Analysis of the Interleukin-2 Receptor Complex: Expression of the Human ? and ? Chain cDNAs.- Interleukin 6 and Its Receptor in Immune Regulation.- The Molecular and Cellular Biology of the IFN? Receptor.- The Regulation of Lymphopoiesis by Interleukin-7.- Signal Transduction in Hematopoietic Cells.- Membrane Immunoglobulins Are Associated with a Family of Membrane Phosphoproteins.- Molecular Components of the IgM Antigen Receptor Complex.- Membrane Immunoglobulin Is Associated with a Phosphoprotein Complex.- Signalling via Surface Immunoglobulin, Fc? and Interleukin-4 Receptors on B Lymphocytes.- Is There Specificity Involved in Fc? Receptor Aggregation Which Leads to an Effective Secretory Stimulus?.- The Association of p561ck with the CD4/CD8 Antigens: Implications for T-Cell Function.- Signal Transduction by the T Cell Antigen Receptor.- Molecules and Cells in Allergic Reactions.- Molecular Biology of Mast Cell Secretory Granule Proteoglycans and Proteases.- Differentiation of Mast Cells and Phenotypic Change Between Subpopulations.- Nerves, Neuropeptides and Mast Cells.- The High Affinity Receptor for Immunoglobulin E: New Developments.- Fee R2/CD23: Regulation and Functional Roles in Cell Activation.- Human Eosinophils: Synthesis and Expression of CD4 and Class II MHC Proteins.- Effector Function of Eosinophils: Isotype-Dependent Activation.- Inflammation.- Endothelial Activation and Inflammation.- Pathogenesis of Tissue Fibrosis: Growth Factor Gene Expression in Mononuclear Phagocytes.- Inflammation and Angiogenesis.- Novel Neutrophil-Activating Peptides and Their Role in Inflammation.- Neuromediators of Immunity and Inflammation.- Cytokine Induced Changes in the Endothelial Cell Surface Membrane: Significance for Lymphocyte Traffic in Inflammation.- Autoimmunity.- Paul Ehrlich and the Foundations of Autoimmunity.- The Physiology of Autoimmune Reactivities.- Reverse Immunogenetics: Investigations of HLA-Associated Disease Based on the Structural and Genetic Identification of Candidate Susceptibility Genes.- Autoimmunity in the Nervous System: Functional Properties of an Encephalitogenic Protein.- Inflammatory Destruction of Pancreatic Islets in Interferon Gamma Transgenic Mice.- Tolerance in Transgenic Mice to a Non-MHC Self-Protein is not a Result of Clonal Deletion.- Autoabzyme Catalyzed Cleavage of Vasoactive Intestinal Peptide.- Evidence Suggesting a Retroviral Etiology for Human Autoimmune Disease.- Suppression.- Is Genes in the Mouse.- Differential Roles of HLA-DR and DQ in Immune Regulation.- Role of the Veto Phenomenon In Vivo.- T Cell Vaccination and Suppression of Autoimmune Disease.- Antigen Specific Suppressor Cells, Receptors, and Factors.- Extrathymic Acquisition of Tolerance by T Lymphocytes: Is Suppression Involved?.- Antigen Specific T Cell Nonresponsiveness in Man: Lepromatous Leprosy, a Model Disease.- IV Defense.- Virus-host Relationships.- CD4+ and CD8+ T Cells in Murine Virus Infections: Experiments with Lymphocytic Choriomeningitis and Influenza.- Immune-Protection Versus Immunopathology by Antiviral T Cell Responses.- Recognition of Viral Antigens by Cytotoxic T Lymphocytes.- Blockade of MHC Class I Molecule Transport from the Endoplasmic Reticulum Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes.- Measlesvirus-Induced Cellular Autoimmune Reactions.- Requirements for Recognition of Epstein-Barr Virus-Infected Target Cells by Human Cytotoxic T Lymphocytes.- Molecular Analysis of the Protective Immune Response to Murine Cytomegalovirus.- Bacterial and Parasitic Infections.- Insights into Immunoregulation and Pathogenesis from a Third World Disease.- Effector T Cells in Bacterial Infections.- Experimental Infection of Mice with Leishmania Major: Analysis of the Role ofT Cells in Resistance and Susceptibility.- Progress Towards Vaccination Against Schistosomiasis.- Antigenic Diversity: Implications for Vaccine Design.- Genetic Aspects of Mycobacterial Infections in Mouse and Man.- Acquired Immunodeficiency Syndrome.- An Introduction into the Immunology of AIDS.- Genetic Regulation of HIV.- The Role of CD4 Antigen in HIV Infection.- Immunopathogenic Mechanisms of HIV Infection.- Immunobiology of the HIV Envelope and Its Relationship to Vaccine Strategies.- The SCID-hu Mouse: A Small Animal Model for HIV Infection and Antiviral Testing.- Tumor Immunology.- Structural Basis for Tumor Cell Recognition by the Immune System.- Genes Coding for TUM- Transplantation Antigens. A Model for TSTA ?.- Regulation and Functional Role of MHC Expression on Tumors.- Immunological Analysis of Micrometastases and the Metastatic Phenotype of Human Tumors.- Basic Aspects of Immunotherapy of Human Tumors.- T Cell-Mediated Tumor Regression in Experimental Systems.- Apoptosis in Monoclonal Antibody-Induced Tumor Regression.- V Preventive and Therapeutic Manipulations.- Vaccination.- An Introduction to Vaccines: An Old Problem in a New Setting.- High Degeneracy of HLA DR-Peptide Interactions: Possible Ramifications for Vaccine Design.- T and B Cell Recognition of Hepatitis B Viral Antigens: Implications for Vaccine Design.- Vaccinia Virus Vectors: Applications to Vaccines.- Peptide Binding to MHC Class II Molecules: Applications to Vaccine Design.- Expression and Secretion of Repertoires of VH Domains inEscherichia Coli: Isolation of Antigen Binding Activities.- Transplantation.- Prospects for Transplantation.- Antigen, Cytokines, and the Regulation of the Allograft Response.- Mixed Chimerism and Transplantation Tolerance.- Pathology and Immunopathology of Rejection and Graft-Versus-Host Disease in Bone Marrow Transplantation.- Graft Host Interactions Following T-Cell Depleted Marrow Transplants.- Rapamycin: A New and Highly Active Immunosuppressive Macrolide with an Efficacy Superior to Cyclosporine.- Immune Intervention.- IL-2 Receptor-Directed Immunotherapy: A Model of Immune Intervention.- Cytokine Therapy of Patients with Cancer.- Modulation of Autoimmune Responses with Normal Polyspecific IgG for Therapeutic Use.- Biological Response Modification of “Physiological” Doses of Recombinant Cytokines.- Origins and Elements of Immune Systems.- The Evolution of the Immune System: An Introduction.- Protein-Protein Interactions and Immune Recognition.- Evolutions of the Immune System.- Allorecognition in Colonial Tunicates: Parallels with and Tangents from Vertebrate Immunity.- Elements of the Human Immune System: Studies of Mature Lymphoid Cells Following Xenotransplantation to Seid Mice.
| Erscheinungsdatum | 20.12.2018 |
|---|---|
| Mitarbeit |
Stellvertretende Herausgeber: L. Nicklin |
| Zusatzinfo | CI, 1318 p. 140 illus. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie |
| Schlagworte | Antigen • Autoimmune Krankheiten • Hybridization • Immunologie • Immuntherapie • Impfung • Infections • Onkologie • Transplantation • Virologie (AIDS) |
| ISBN-10 | 3-642-83757-3 / 3642837573 |
| ISBN-13 | 978-3-642-83757-9 / 9783642837579 |
| Zustand | Neuware |
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