Advances in Micro-Bioreactor Design for Organ Cell Studies

Buch | Softcover

168 Seiten

2018
MDPI (Verlag)
978-3-03897-233-4 (ISBN)

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Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or using bioreactors for the production of biologics.
This book highlights these issues with a strong focus on new engineering design. The initial chapters cover the conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for clinical and therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumor models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and the integration of sensors are covered in separate chapters. We believe the book will have substantial value for researchers active in bioreactor engineering, drug development and cell physiology, as well as readers interested in these topics.

Division of Biotechnology/IFM, Linköping University

Erscheinungsdatum	05.03.2022
Mitarbeit	Gast Herausgeber: Carl-Fredrik Mandenius
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	3d models • Bioprocess Development • drug testing • Heart-on-a-chip • in vitro assay • liver-on-a-chip • microbioreactor design • Toxicity testing • tumour-on-a-chip
ISBN-10	3-03897-233-9 / 3038972339
ISBN-13	978-3-03897-233-4 / 9783038972334
Zustand	Neuware