Bioinformatics and Drug Discovery

Richard S. Larson, Tudor I. Oprea (Herausgeber)

Buch | Hardcover

324 Seiten

2019 | 3rd ed. 2019
Humana Press Inc. (Verlag)
978-1-4939-9088-7 (ISBN)

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This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics. The chapters discuss new methods to study target identification, genome analysis, cheminformatics, protein analysis, and text mining. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, software workflows, reagents and on-line resources, together with step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Bioinformatics and Drug Discovery, Third Edition is a valuable resource for anyone interested in drug design, including academicians (biologists, informaticists and data scientists, chemists, and biochemists), clinicians, and pharmaceutical scientists.

Miniaturized Checkerboard Assays to Measure Antibiotic Interactions.- High-Throughput Screening for Drug Combinations.- Post-Processing of Large Bioactivity Data.- How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM).- A Guide to Dictionary-Based Text Mining.- Leveraging Big Data to Transform Drug Discovery.- How to Prepare a Compound Collection Prior to Virtual Screening.- Building a Quantitative Structure-Property Relationship (QSPR) Model.- Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility Mass Spectrometry (IM-MS).- A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine.- Omics Data Integration and Analysis for Systems Pharmacology.- Bioinformatics Based Tools and Software in Clinical Research: A New Emerging Area.- Text Mining for Drug Discovery.- Big Data Cohort Extraction for Personalized Statin Treatment and Machine Learning.- Drug Signature Detection Based on L1000 Genomic and Proteomic Big Data.- Drug Effect Prediction by Integrating L1000 Genomic and Proteomic Big Data.- A Bayesian Network Approach to Disease Subtype Discovery.

Erscheinungsdatum	22.03.2019
Reihe/Serie	Methods in Molecular Biology ; 1939
Zusatzinfo	54 Illustrations, color; 9 Illustrations, black and white; XI, 324 p. 63 illus., 54 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Mathematik / Informatik ► Informatik ► Theorie / Studium
	Informatik ► Weitere Themen ► Bioinformatik
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik
Schlagworte	Clinical research informatics • Computational approaches • Data Mining • drug discovery • Informatics • Translational Bioinformatics
ISBN-10	1-4939-9088-8 / 1493990888
ISBN-13	978-1-4939-9088-7 / 9781493990887
Zustand	Neuware