IgM and Its Receptors and Binding Proteins

Hiromi Kubagawa, Peter D. Burrows (Herausgeber)

Buch | Softcover

IX, 117 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-87810-2 (ISBN)

Artikel merken

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fc /µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, Germany Peter D. Burrows, PhD, is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA

The appearance and diversification of receptors for IgM during vertebrate evolution..- Authentic IgM Fc Receptor (FcmiR).- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells.- Specific IgM and regulation of antibody responses.- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.

Erscheinungsdatum	25.09.2018
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IX, 117 p. 30 illus., 15 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	2058 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Antibody response • Fc receptor • Fc-receptor evolution • FCRLA • Fcα/µR • Fc /µR • Fc/µR • FcµR • iga • Infectious Diseases • natural antibodies • pIgR
ISBN-10	3-319-87810-7 / 3319878107
ISBN-13	978-3-319-87810-2 / 9783319878102
Zustand	Neuware