Inhalation Aerosols
CRC Press (Verlag)
978-1-138-06479-9 (ISBN)
Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years.
In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies.
The final integrated strategies section draws the major points from the applications for disease targets and drug products.
Anthony J. Hickey, PhD, DSc, is Distinguished RTI Fellow, at the Research Triangle Institute (2010-present), Emeritus Professor of Molecular Pharmaceutics of the Eshelman School of Pharmacy (1993-2010), and Adjunct Professor Biomedical Engineering in the School of Medicine at the University of North Carolina at Chapel Hill. He obtained PhD (1984) and DSc (2003) degrees in pharmaceutical sciences from Aston University, Birmingham, United Kingdom, following postdoctoral positions at the University of Kentucky (1984-1988). Dr. Hickey then joined the faculty at the University of Illinois at Chicago (1988-1993). In 1990, he received the Association of Pharmaceutical Scientists (AAPS) Young Investigator Award in Pharmaceutics and Pharmaceutical Technology. He is a Fellow of the Royal Society of Biology (2000), the American Association of Pharmaceutical Scientists (2003), the American Association for the Advancement of Science (2005), and the Royal Society of Biology (2017). He received the Research Achievement Award of the Particulate Presentations and Design Division of the Powder Technology Society of Japan (2012), the Distinguished Scientist Award of the American Association of Indian Pharmaceutical Scientists (2013), the David W. Grant Award in Physical Pharmacy of the American Association of Pharmaceutical Scientists (2015), the Thomas T. Mercer Joint Prize for Excellence in Inhaled Medicines and Pharmaceutical Aerosols of the American Association for Aerosol Research and the International Society for Aerosols in Medicine (2017). He has published numerous papers and chapters (over 250) in the pharmaceutical and biomedical literature, one of which received the AAPS Meritorious Manuscript Award in 2001. He has edited five texts on pharmaceutical inhalation aerosols and co-authored three others on pharmaceutical process engineering, pharmaceutical particulate science, and pharmaco complexity. He holds 25 U.S. patents on a variety of inhaler device technologies, and pulmonary and oral drug delivery formulation technologies. He is founder (1997, and formerly president and CEO, 1997-2013) of Cirrus Pharmaceuticals, Inc., which was acquired by Kemwell Pharma in 2013; founder (2001, and formerly CSO, 2002-2007) of Oriel Therapeutics, Inc, which was acquired by Sandoz in 2010; and founder and CEO of Astartein, Inc. (2013-present). He is a member of the Pharmaceutical Dosage Forms Expert Committee of the United States Pharmacopeia (USP, 2010–2015, Chair of the Subcommittee on Aerosols), and formerly Chair of the Aerosols Expert Committee of the USP (2005-2010). Dr. Hickey conducts a multidisciplinary research program in the field of pulmonary drug and vaccine delivery for treatment and prevention of a variety of diseases. Heidi M. Mansour, PhD, RPh, is a tenured Associate Professor of Pharmaceutical Sciences in the College of Pharmacy with joint faculty appointments in the BIO5 Research Institute and the College of Medicine in the Division of Translational and Regenerative Medicine at The University of Arizona (UA) in Tucson, Arizona. Dr. Mansour has faculty member affiliations in the UA Institute of the Environment, and the UA NCI Comprehensive Cancer Center. She lectures in the BS Pharmaceutical Sciences undergraduate program, the Pharm.D. professional program and in the Pharmaceutics and Pharmacokinetics track of the graduate program at The University of Arizona. In addition to teaching, Dr. Mansour serves as Faculty Advisor in the Pharm.D./PhD Dual Degree Joint Program and Director of the Pharmaceutics and Pharmacokinetics track in the Pharmaceutical Sciences graduate program in The UA College of Pharmacy. Dr. Mansour has published over 80 peer-reviewed scientific journal papers, 9 book chapters, 2 edited books, and over 100 scientific conference abstracts. She serves on the editorial advisory boards of the the Royal Society of Chemistry Molecular Systems Design & Engineering, APhA/FIP Journal of Pharmaceutical Sciences, and Pharmaceutical Technology. Dr. Mansour is an annual Faculty Instructor at ISAM (International Society of Aerosols in Medicine) Aerosol School, instructor in two online webinars on inhalation aerosol drug delivery, and instructor in Buchi Advanced Spray Drying short courses. She was recently Co-Chair of the Drug Delivery: New Devices & Emerging Therapies Group in (ISAM, and has been an expert member of the National Institutes of Health (NIH) NICHD U.S. Pediatric Formulations Initiative New Drug Delivery Systems Aerosols Working Group for several years. Dr. Mansour currently serves on the Drug/Device Discovery and Development (DDDD) Committee of the American Thoracic Society (ATS). She regularly serves as an expert reviewer for scientific journals and grant funding agencies including NIH study sections; Department of Defense (DOD) study panels; National Science Foundation (NSF) study panels; the American Association for the Advancement of Science (AAAS); Catalent Drug Delivery Institute; and international funding agencies such as the German-Israeli Foundation, German International Exchange Service (DAAD), Cochrane Airways Group of the National Health Service (London, England), Engineering and Physical Sciences Research Council (London, England), PRESTIGE Postdoc Fellowship Programme of the European Commission (Paris, France), and the Biomedical Innovation Program of the French National Research Agency (Paris, France). In addition to serving on NSF study panels, NIH study sections, and international study panels in the European Union and Great Britain, her innovative research program continuously attracts competitive funding awards from federal sources (NIH, NSF, FDA, DOD) and the pharmaceutical industry. In addition to lecturing in the BS Pharmaceutical Sciences undergraduate, PhD graduate, and Pharm. D. professional programs, Dr. Mansour leads her research labs where she trains postdoctoral scholars, visiting scholars, visiting professors, graduate students, Pharm. D. student researchers, and physician-scientist (MD/PhD) fellows. As Major Professor and mentor, her research program has successfully graduated several PhDs. Her innovative research program has produced assistant professors employed at research universities in the United States and in the Republic of South Korea, and senior research scientists employed at major pharmaceutical companies in the United States. Dr. Mansour is an active, long-time member of several scientific organizations and elected member to honor societies, including the Sigma Xi Scientific Research Honor Society, Rho Chi Pharmaceutical Honor Society, and Golden Key International Honor Society. As a registered pharmacist for over 20 years, she earned her BS in pharmacy with honors and distinction, a PhD minor in advanced physical and interfacial chemistry (Department of Chemistry), and a PhD major in drug delivery/pharmaceutics (School of Pharmacy) from the University of Wisconsin-Madison. Also at the University of Wisconsin-Madison, she was a clinical instructor for a few years. Having completed postdoctoral fellowships at the University of Wisconsin-Madison and at the University of North Carolina (UNC)-Chapel Hill, she was awarded the UNC-Chapel Hill Postdoctoral Award for Research Excellence from the Office of the Vice-Chancellor, the AAPS Postdoctoral Fellow Award in Research Excellence, and the PhRMA Foundation Postdoctoral Fellowship Award. As an Instructor, she served on the Graduate Faculty at UNC-Chapel Hill.
PART I Fundamentals. 1. Physicochemical Properties of Respiratory Particles and Formulations. 2. Particle Deposition in the Respiratory Tract and the Effect of Respiratory Disease. 3. Mathematical Modeling of Inhaled Therapeutic Aerosol Deposition in the Respiratory Tract. 4. Lung Transporters and Absorption Mechanisms in the Lungs. 5. Bioavailability of Inhaled Compounds. 6. 3D Models as Tools for Inhaled Drug Development. 7. Overview of the Delivery Technologies for Inhalation Aerosols. PART II Applications, Influence of Lung Disease Pathophysiology on Aerosol Deposition, Inhaler Device Technique in Respiratory Disease, and Clinical Outcomes in Drug Performance Assessment. 8. Neonatal and Pediatric Inhalation Drug Delivery. 9. Asthma. 10. Drug Delivery in Pulmonary Aspergillosis. 11. Lung Cancer Inhalation Therapeutics. 12. Inhaled Therapeutics in Chronic Obstructive Pulmonary Disease. 13. Cystic Fibrosis Infection and Biofilm Busters. 14. Current and Future CFTR Therapeutics. 15. Innate and Adaptive Barrier Properties of Airway Mucus. 16. Nontuberculous Mycobacteria. 17. Inhalational Therapies for Non-Cystic Bronchiectasis. 18. Pulmonary Fibrosis. 19. Therapeutics in Pulmonary Hypertension. 20. Overview of Lung Surfactant and Respiratory Distress Syndrome. 21. Surfactant Aerosol Therapy for nRDS and ARDS. 22. Fundamentals in Nasal Drug Delivery. 23. Inhaled therapeutics against TB: The Promise of Pulmonary Treatment and Prevention Strategies in the Clinic. PART III Integrated Strategies (Reflecting Combined Elements from Chapters 8 through 23). 24. Inhaled Medication: Factors That Affect Lung Deposition. 25. A Critical Perspective on Future Developments Based on the Knowledge We Have Now. 26. Ensuring Effectiveness and Reproducibility of Inhaled Drug Treatment. 27. Conclusion.
| Erscheinungsdatum | 25.03.2019 |
|---|---|
| Reihe/Serie | Lung Biology in Health and Disease |
| Zusatzinfo | 55 Illustrations, color; 46 Illustrations, black and white |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 210 x 280 mm |
| Gewicht | 1454 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Pneumologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Sportmedizin | |
| ISBN-10 | 1-138-06479-3 / 1138064793 |
| ISBN-13 | 978-1-138-06479-9 / 9781138064799 |
| Zustand | Neuware |
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