The Origin of a New Progenitor Stem Cell Group in Human Development
Springer International Publishing (Verlag)
978-3-030-02049-1 (ISBN)
This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs.
The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets.
These newly detected stem cells represent a specific developmental step which is found only in humans.
Chapter 1. Distribution of progenitor stem cells from the AMG-system an the adrenal.- Chapter 2. Development of the adrenal medulla and other endocrine glands.- Chapter 3. Final view on stem cell origin during human development.
"This expert-level book is most appropriate for developmental biologists with an understanding of embryology and histology. ... The book includes numerous light- and electron-microscope images that complement the main points. ... This monograph offers a unique hypothesis on the origin and migration of a newly identified source of fetal stem cells." (Erin Rae Leslie, Doody's Book Reviews, June 07, 2019)
| Erscheinungsdatum | 25.01.2019 |
|---|---|
| Reihe/Serie | Advances in Anatomy, Embryology and Cell Biology |
| Zusatzinfo | XII, 79 p. 78 illus., 2 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 158 g |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Schlagworte | AMG-region • autonomic nervous system • Gonadal and Intestine stem cells • Guided axonal migration • pancreas • Para-aortal plexus • Paraganglia • Progenitor stem cells • Stem cells II, APUD-system • teratoma • Zona definitiva |
| ISBN-10 | 3-030-02049-5 / 3030020495 |
| ISBN-13 | 978-3-030-02049-1 / 9783030020491 |
| Zustand | Neuware |
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