Mitochondrial Dysfunction in Neurodegenerative Disorders
Springer International Publishing (Verlag)
978-3-319-80394-4 (ISBN)
This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson's disease, Alzheimer's disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets.
Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins.
Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.
Amy K. Reeve Amy did her undergraduate degree in Neuroscience at Edinburgh University before moving to the Mitochondrial Research Group at Newcastle University for her PhD studies. She completed her PhD in the study of the molecular mechanisms of neurodegenerative disease in 2007 and now has her own research group within the Wellcome Trust Centre for Mitochondrial Research. Her current research interests centre around understanding the mechanisms behind the neurodegeneration seen in Parkinson's disease, and the contribution of mitochondrial dysfunction to these changes. Funded by Parkinson's UK as a research fellow Amy's interests lie in understanding how changes within mitochondria, mitochondrial transport and the interaction of mitochondrial with alpha-synuclein contributes to the development of Parkinson's disease.
Part I.Mitochondria and Neurodegenerative Disease.- An Introductionto Mitochondria, Their Structure and Functions.- Part II.Mitochondrial Dysfunction: Causes and Effects?.- Neurodegeneration in Mitochondrial Disorders.- The Ageing Brain,Mitochondria and Neurodegeneration.- Mitochondrial Genes and Neurodegenerative Disease.- MitochondrialSignalling and Neurodegeneration.- Part III. Functional Consequences ofMitochondrial Dysfunction.- Life on the Edge: Determinants of SelectiveNeuronal Vulnerability in Parkinson's Disease.- MitochondrialDynamics and Neurodegeneration.- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation.-Mitochondria,the Synapse, and Neurodegeneration.- Protein Misfolding andAggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration.-Mitochondrial Degradation, Autophagy andNeurodegenerative Disease.- The DeleteriousDuo of Neurodegeneration: Lysosomes and Mitochondria.- PartIV. Measuring theContribution of Mitochondrial Dysfunction to Neurodegenerative Disease.- CanWe Accurately Model Mitochondrial Dysfunction in Neurodegeneration?.- MitochondrialFunction and Dynamics Imaged In Vivo.-Part V. The Future.- Developmentof Treatments and Therapies to Target Mitochondrial Dysfunction.- Summary and Conclusions.
| Erscheint lt. Verlag | 31.5.2018 |
|---|---|
| Zusatzinfo | XI, 380 p. 34 illus., 29 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 6626 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Schlagworte | Alzheimer's disease • mitochondrial dysfunction • Multiple Sclerosis • Neurodegenration • neurodegenrative disorder • Parkinson's Disease |
| ISBN-10 | 3-319-80394-8 / 3319803948 |
| ISBN-13 | 978-3-319-80394-4 / 9783319803944 |
| Zustand | Neuware |
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