Translational Toxicology
Springer International Publishing (Verlag)
978-3-319-80143-8 (ISBN)
Bringing together adistinguished interdisciplinary team of contributors, this volumeprovides a comprehensive exploration of translational toxicology-a systematicapproach to developing therapeutic interventions that can protect against,mitigate, or reverse the effects of exposures. In particular, the bookaddresses modes of action and biomarkers, developmental risks of exposures, andpotential translational toxicology therapeutics. The result is a compellingapplication of developmental toxicology in a new therapeutic discipline that isdestined to become part of standard medical practice.
TranslationalToxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, andphysicians who are concerned with environmental exposures, public health, nutrition,and pharmaceutical research and development. Basic science, epidemiological,and clinical investigators will also find this book a significant resource.Claude L. Hughes, M.D., Ph.D. is Executive Director in the Therapeutic Science & Strategy Unit within Quintiles Inc. He is board-certified in Obstetrics & Gynecology and Reproductive Endocrinology and Infertility. He is a Consulting Professor in the Department of Obstetrics & Gynecology, Duke University Medical Center and an Adjunct Professor in the Department of Mathematics, North Carolina State University and in the Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine. Since joining Quintiles in 2001, Dr. Hughes has served as a Medical Advisor on clinical trials or in due diligence assessment teams that evaluated pharmaceuticals, devices or tests for several medical indications. Therapeutic areas for clinical trials and/or product evaluation have included the following: 1) Reproductive Medicine - female sex hormone therapy, male sex hormone therapy, contraception, infertility, in vitro fertilization-embryo transfer, polycystic ovary syndrome, SERMs, overactive bladder/urinary incontinence, endometriosis, preterm labor, ovarian cancer, cervical cancer, microbicides, dysmenorrhea, gynecologic infections, female and male sexual dysfunction, erectile dysfunction, BPH/LUTS, delayed puberty in boys, primary and secondary hypogonadism in boys.2) General Endocrinology, Metabolism and Cardiovascular Diseases - osteoporosis prevention and treatment, diabetes mellitus, thyroid hormone replacement, growth hormone therapy in children, hypertension (including use of ambulatory blood pressure monitoring - ABPM) and chronic renal disease.3) Other Medical Conditions - GERD, opioid-induced constipation, rheumatoid arthritis, sleep disorders, migraine headaches, neuropathic pain and psoriasis. 4) Laboratory Testing Methods - genital cytologic screening and molecular biomarker screening.5) Drug Delivery - new systems for transdermal, buccal or vaginal administration of drugs. Prior to joining Quintiles, Dr. Hughes held academic, research, administrative and clinical practice positions for 15 years in divisions of reproductive endocrinology & infertility in departments of obstetrics & gynecology and clinical and research centers within university-affiliated medical centers. His academic research emphasized investigating the effects of natural and man-made sex hormone-like compounds in the diet in laboratory animal and human studies. Continuing collaborative academic research is supported by a National Science Foundation grant in the Department of Mathematics at North Carolina State University (Dr. Hughes is the co-Principal Investigator). Since April 2008, Dr. Hughes has served as a member of the Metabolic Disorders Steering Committee (MDSC) of The Biomarkers Consortium, the public-private biomedical research partnership managed by the Foundation for the National Institutes of Health (FNIH) that includes government, industry, patient advocacy groups, and other non-profit private sector organizations such as the National Institutes of Health, the Food and Drug Administration, and the Pharmaceutical Research and Manufacturers of America. Michael D. Waters is a former government scientist with more than 35 years of experience in research and research management positions at US EPA and NIH/National Institute of Environmental Health Sciences in Research Triangle Park, NC USA. He retired as Chief Scientist, Emeritus, from Integrated Laboratory Systems (ILS), Inc. in 2013. He served as Assistant Director of the NIEHS National Center for Toxicogenomics from 2000 to 2007, and was responsible for a major initiative to develop the Chemical Effects in Biological Systems (CEBS) toxicogenomics knowledgebase. CEBS is now the data repository of the US National Toxicology Program and is being utilized by the NIH and other government agencies as well as the academic, industrial, and international regulatory scientific communities for the deposition, retrieval and interpretation of toxic
I.Introduction.- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline.- TheRole of Toxicokinetics and Toxicodynamics in Developmental and TranslationalToxicology.- II.Toxicant Modes of Action and Biomarkers.- Mutational Effects.- Ligand-Mediated Toxicology: Characterization and Translational Prospects.- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype.- Fetal Imaging and Effects of Exposures on Growth and Function.- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics.- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey.- The"Toxic" Effects of a Perinatal Obesogenic Environment: Maternal Obesity andImpacts on Future Generations.- The Role of Environmental Exposures in Preterm Birth.- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions.- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.
| Erscheint lt. Verlag | 25.4.2018 |
|---|---|
| Reihe/Serie | Molecular and Integrative Toxicology |
| Zusatzinfo | XV, 380 p. 32 illus., 12 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 6692 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Arbeits- / Sozial- / Umweltmedizin |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Pharmazie | |
| Schlagworte | Biomarker • endocrine disruptor • Environmental Exposure • susceptability • Therapeutic Intervention |
| ISBN-10 | 3-319-80143-0 / 3319801430 |
| ISBN-13 | 978-3-319-80143-8 / 9783319801438 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
