Vaccines for Invasive Fungal Infections

Methods and Protocols

Markus Kalkum, Margarita Semis (Herausgeber)

Buch | Softcover

358 Seiten

2018 | Softcover reprint of the original 1st ed. 2017
Humana Press Inc. (Verlag)
978-1-4939-8385-8 (ISBN)

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This detailed volume focuses on the development of mycosis vaccines via the most common etiological agents of mycoses, such as Aspergillus and Candida species, followed by Cryptococcus, dimorphic fungi, and members of Mucoraceae family of fungi. The book is sectioned into five parts that describe experimental approaches for vaccine candidate discovery, improved vaccine design and delivery, assessment of critical endpoints, analysis of mechanisms of mycosis vaccine protection, and key methods for clinical translation. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting known pitfalls.
Practical and authoritative, Vaccines for Invasive Fungal Infections: Methods and Protocols provides a standard reference forvaccine researchers, including those who aspire to strengthen their knowledge or desire to acquire a particular technique.

Mouse Immunization with Radioattenuated Yeast Cells of Paracoccidioides brasiliensis.- Heat-Killed Yeast as a Pan-Fungal Vaccine.- Immunoinformatics as a Tool for New Antifungal Vaccines.- Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection.- Identification of Fungal T Cell Epitopes by Mass Spectrometry-Based Proteomics.- Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells.- DNAhsp65 Vaccine as Therapy Against Paracoccidioidomycosis.- Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies.- Peptide Vaccine Against Paracoccidioidomycosis.- Methodology for Anti-Cryptococcal Vaccine Development.- Beta-Glucan Particles as Vaccine Adjuvant Carriers.- Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis.- Nanoparticle-Based Mycosis Vaccine.- Yeast Expressing Gp43 Protein as a Vaccine Against Paracoccidioides brasiliensis Infection.- Vaccination with Phage-Displayed Antigenic Epitope.- Preparation of an Oral Vaccine by Proteome Analysis and Molecular Display Technology.- Precise and Efficient In-Frame Integration of an Exogenous GFP Tag in Aspergillus fumigatus by a CRISPR System.- Endpoint Assessment in Rabbit Models of Invasive Pulmonary Aspergillosis and Mucormycosis.- CD4+ T Cells Mediate Aspergillosis Vaccine Protection.- T-Cell-Mediated Cross-Protective Immunity.- Assessment of Post-Vaccination Phagocytic Activation Using Candida albicans Killing Assays.- Immunization with Antigen-Pulsed Dendritic Cells Against Highly Virulent Cryptococcus gattii Infection: Analysis of Cytokine-Producing T Cells.- Testing Antifungal Vaccines in an Animal Model of Invasive Candidiasis and in Human Mucosal Candidiasis.

Erscheinungsdatum	18.08.2018
Reihe/Serie	Methods in Molecular Biology ; 1625
Zusatzinfo	49 Illustrations, color; 20 Illustrations, black and white; XII, 358 p. 69 illus., 49 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Aspergillus and Candida species • Clinical translation • Endpoint assessment • Fungal pathogens • Immunosuppressive conditions • Invasive mycosis vaccines • Mycoses • Vaccine design and delivery
ISBN-10	1-4939-8385-7 / 1493983857
ISBN-13	978-1-4939-8385-8 / 9781493983858
Zustand	Neuware