The Cadherin Superfamily

Key Regulators of Animal Development and Physiology

Shintaro T. Suzuki, Shinji Hirano (Herausgeber)

Buch | Softcover

428 Seiten

2018 | Softcover reprint of the original 1st ed. 2016
Springer Verlag, Japan
978-4-431-56759-2 (ISBN)

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This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases.

Foreword.- Preface.- Part I Overview.- 1 Introduction.- 2 Evolution of Cadherins and Associated Catenins.- Part II Classical Cadherins.- 3 Classical Cadherins.- 4 Structure and Function of Cadherin Extracellular Regions.- 5 Regulation of Cadherin-Catenin Biology by Mechanical Force and Phosphorylation.- 6 Cooperative Roles of Nectins with Cadherins in Physiological and Pathological Processes.- Part III Atypical Cadherins.- 7 Desmosomal Cadherins.- 8 Clustered Protocadherins.- 9 The Non-clustered Protocadherins.- 10 Seven-Pass Transmembrane Cadherin CELSRs, and Fat4 and Dchs1 Cadherins: From Planar Cell Polarity to Three-Dimensional Organ Architecture.- 11 Various Atypical Cadherins: T-Cadherin, RET, Calsyntenin, and 7-D Cadherin.- Part IV Cadherins in Tissues and Diseases.- 12 Cadherins in Neural Development.- 13 Cadherins in the Auditory Sensory Organ.- 14 Cadherins in Cancer.- 15 Cadherin-Related Diseases.- BM Index.

Erscheinungsdatum	27.08.2018
Zusatzinfo	74 Illustrations, color; 2 Illustrations, black and white; XII, 428 p. 76 illus., 74 illus. in color.
Verlagsort	Tokyo
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Animal Development • Cadherin • Cell adhesion molecule • Cell Biology • cell signaling • human disease • Morphogenesis • nervous system • Physiology
ISBN-10	4-431-56759-3 / 4431567593
ISBN-13	978-4-431-56759-2 / 9784431567592
Zustand	Neuware