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Cell Cycle Inhibitors in Cancer Therapy -

Cell Cycle Inhibitors in Cancer Therapy

Current Strategies
Buch | Hardcover
326 Seiten
2002
Humana Press Inc. (Verlag)
978-0-89603-930-8 (ISBN)
CHF 299,55 inkl. MwSt
Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

1 Cdk Inhibitors: Background and Introduction.- 2 p27, A Prognostic Indicator Reflecting?....- 3 Cell Cycle Control of Transcription at the G1/S Phase Transition.- 4 Tumor-Suppressor Genes as Diagnostic Tools.- 5 Regulation of Cell Cycle and Apoptosis.- 6 CDK Inhibitors as Targets of Chemoprevention Agents.- 7 Cell Cycle Regulatory Genes as Targets of Retinoids.- 8 Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases.- 9 Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer.- 10 Cell Cycle Regulators as Targets of Anticancer Therapy.- 11 Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer.- 12 Synthetic Oligopeptides as Cancer Cell Cycle Modulators.

"Cell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention." -Pharmaceutical Research

Erscheint lt. Verlag 20.11.2002
Reihe/Serie Cancer Drug Discovery and Development
Zusatzinfo 22 Illustrations, black and white; X, 326 p. 22 illus.
Verlagsort Totowa, NJ
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Pharmazie
ISBN-10 0-89603-930-7 / 0896039307
ISBN-13 978-0-89603-930-8 / 9780896039308
Zustand Neuware
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