Antiepileptic Drug Discovery

Novel Approaches

Buch | Softcover

386 Seiten

2018 | Softcover reprint of the original 1st ed. 2016
Humana Press Inc. (Verlag)
978-1-4939-8174-8 (ISBN)

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This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory.
Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

Inflammatory Cytokines as Targets for Epilepsy Drug Therapy.- The Use of Anti-Inflammatory Drugs in Epilepsy.- Carbonic Anhydrase and Epilepsy.- Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs.- Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?.- Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy.- Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity.- Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy.- Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery.- Gene Therapy in Epilepsy.- Human Brain Tissue as a Model for the Study of Epilepsy.- The Blood-Brain Barrier and the Design of New Antiepileptic Drugs.- Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates.- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations.- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations.- Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies.- Side Effects of Antiepileptic Drugs.- Network Pharmacology and Epilepsy.- The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development.

Erscheinungsdatum	16.08.2018
Reihe/Serie	Methods in Pharmacology and Toxicology
Zusatzinfo	42 Illustrations, color; 9 Illustrations, black and white; XI, 386 p. 51 illus., 42 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	Antiepileptogenesis • Computer-aided approaches • Drug repurposing • Epilepsy treatment • Multi-drug resistance • Network Pharmacology • Pharmaceutical screening
ISBN-10	1-4939-8174-9 / 1493981749
ISBN-13	978-1-4939-8174-8 / 9781493981748
Zustand	Neuware