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Long Non-coding RNAs in Human Disease -

Long Non-coding RNAs in Human Disease

Kevin V. Morris (Herausgeber)

Buch | Softcover
VIII, 262 Seiten
2018 | 2016
Springer International Publishing (Verlag)
978-3-319-79551-5 (ISBN)
CHF 209,70 inkl. MwSt
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Thisvolume focuses on the roles of long non-coding RNAs (lncRNAs) in contextsranging from human cancers to cardiovascular disease and ageing. The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail. Further,the book examines the function of lncRNAs in diseases such as diabetes, in smoothmuscle formation, and in the modulation of nuclear receptors, as well as inconnection with perspectiveson the development ofpersonalized therapeutics. It offers an appealing and insightful resource forscientists and clinicians alike.

Kevin Morris is an Associate Professor at the Department of Molecular and Experimental Medicine, The Scripps Research Institute in La Jolla, CA, USA. The responsible series editor is Peter K. Vogt, The Scripps Research Institute in La Jolla, CA, USA.

Understandingthe Complex Circuitry of lncRNAs at the X-inactivation Center and itsImplications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb inHuman Cancers and Cardiovascular Disease.- Form and function of exosomeassociated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.-Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functionallong non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs asTargets and Regulators of Nuclear Hormone Receptors.- Non-codingtranscriptional landscape in human aging.- LncRNAs in stress response.- ExpressionSpecificity of Disease-Associated lncRNAs: towards Personalized Medicine.

 

Erscheinungsdatum
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo VIII, 262 p.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 4161 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Studium Querschnittsbereiche Infektiologie / Immunologie
Schlagworte ANRIL • Cellular stress response • Epigenetic loss-of-function disease • Exosome associated lncRNAs • lncRNA • Non-protein-coding transcriptome • Nuclear hormone receptors • Polycomb • prostrate cancer • Pseudogene-expressed RNAs • T-cell mediated immunity • tumor suppressor genes
ISBN-10 3-319-79551-1 / 3319795511
ISBN-13 978-3-319-79551-5 / 9783319795515
Zustand Neuware
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