Mouse Models for Drug Discovery
Humana Press Inc. (Verlag)
978-1-4939-8109-0 (ISBN)
With genetic engineering, systems explored in this book now exist allowing
for the simple, efficient, and near universally precise genetic manipulation
directly in any organism, including the mouse. Herein, these models are applied
to a wide field of disease areas, including diabetes, cardiovascular disease,
skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal
disorders, as well as various behavioral models. Written for the highly
successful Methods in Molecular Biology
series, chapters include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily reproducible laboratory
protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical
and fully updated, Mouse Models for Drug
Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview
of techniques to utilize the many possibilities of mice in the drug development
process.
Genetically Defined Strains in Drug
Development and Toxicity Testing.- Simple, Efficient CRISPR-Cas9
Mediated Gene Editing in Mice: Strategies and Methods.- Mouse Sperm Cryopreservation and
Recovery of Genetically Modified Mice.- Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment
of Hematopoietic Stem Cells.- Generation of Human Liver Chimeric
Mice for the Study of Human Hepatotropic Pathogens.- Human FcRn Transgenic Mice for
Pharmacokinetic Evaluation of Therapeutic Antibodies.- A Humanized Mouse Model to Study
Human Albumin and Albumin Conjugates Pharmacokinetics.- Germ-Free Mice Model for Studying
Host-Microbial Interactions.- Bridging Mice to Men: Using HLA
Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune
Type 1 Diabetes in Humans.- Mouse Models of Type 2 Diabetes
Mellitus in Drug Discovery.- Cholesterol Absorption and
Metabolism.- Skin Diseases in Laboratory Mice:
Approaches to Drug Target Identification and Efficacy Screening.- Chronic Myeloid Leukemia (CML) Mouse
Model in Translational Research.- Murine Model for Colitis-Associated
Cancer of the Colon.- Mouse Models for Studying
Depression-Like States and Antidepressant Drugs.- Experimental Models of Anxiety for
Drug Discovery and Brain Research.- Repetitive Behavioral Assessments
for Compound Screening in Mouse Models of Autism Spectrum Disorders.- Better Utilization of Mouse Models
of Neurodegenerative Diseases in Preclinical Studies: From the Bench to the
Clinic.- Neuromuscular Disease Models and
Analysis.- Brightfield Imaging and Optical Coherence Tomography of the Mouse
Posterior Eye.- Mouse
Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as
Exemplified by Leber's Congenital Amaurosis.
| Erscheinungsdatum | 24.06.2018 |
|---|---|
| Reihe/Serie | Methods in Molecular Biology ; 1438 |
| Zusatzinfo | 37 Illustrations, color; 26 Illustrations, black and white; XI, 436 p. 63 illus., 37 illus. in color. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Schlagworte | Animal Models • drug development • Genetic Engineering • Humanized mice • Pharmaceutical design |
| ISBN-10 | 1-4939-8109-9 / 1493981099 |
| ISBN-13 | 978-1-4939-8109-0 / 9781493981090 |
| Zustand | Neuware |
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