Methionine Dependence of Cancer and Aging

Methods and Protocols

Buch | Hardcover

329 Seiten

2019 | 1st ed. 2019
Humana Press Inc. (Verlag)
978-1-4939-8795-5 (ISBN)

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This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, MethionineDependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study."

Methods to Study the Role of Methionine Restricted Diet and Methioninase in Cancer Growth Control.- Altered Methionine Metabolism in Cancer Cells.- Linkage of Methionine-Dependence and Other Features of Malignancy.- Isolation and Characterization of Methionine Independent Clones from Methionine Dependent Cancer Cells.- Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction.- Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction.- Efficacy of Methionine-Restricted Diets on Cancers In Vivo.- Dietary Methionine-Restriction Based Cancer Chemotherapy in Rodents.- Clinical Studies of Methionine-Restricted Diets for Cancer Patients.- Development of Recombinant Methioninase for Cancer Treatment.- Methioninase Cell-Cycle Trap Cancer Chemotherapy.- High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.- Total Methionine Restriction Treatment of Cancer.- Methioninase Gene Therapy.- Selenomethionine and Methioninase: Selenium Free Radical Anti-Cancer Activity.- Super and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.- Pilot Phase 1 Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.- Methionine Gamma Lyase from Clostridium sporogenes Increases the Anti-Cancer Effect of Doxorubicin in A549 Cancer Cells In Vitro and Human Cancer Xenografts.- Methionine Restriction and Life-Span Extension.- L-[methyl-11C] Methionine-Positron Emission Tomography (MET PET).- Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer?.- Recombinant Methioninase as a DNA Demethylation Agent.- Homocysteine, Thioretinaco Ozonide and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial Protocol.- Afterword - Oral Methioninase: Answer to Cancer and Foundation of Youth?.

Erscheinungsdatum	05.10.2018
Reihe/Serie	Methods in Molecular Biology ; 1866
Zusatzinfo	34 Illustrations, color; 46 Illustrations, black and white; XII, 329 p. 80 illus., 34 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Medizin / Pharmazie ► Studium
Schlagworte	METase • methioninases • Polyethylene Glycol • rMETase • Warburg Effect
ISBN-10	1-4939-8795-X / 149398795X
ISBN-13	978-1-4939-8795-5 / 9781493987955
Zustand	Neuware