Syntheses of nipecotic acid derivatives with new N-arylalkenyl and N-arylalkynyl substituents and new photoswitchable residues as mGAT1 inhibitors

Toni Alexander Lutz (Autor)

Buch | Softcover

185 Seiten

2018
Dr. Hut (Verlag)
978-3-8439-3587-6 (ISBN)

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A new series of nipecotic acid derivatives with N-arylalkenyl and N-arylalkynyl substituents has been developed exhibiting noticeably high and selective inhibitory potencies towards the GABA transporter subtype 1. In this context the aromatic part of these residues was additionally replaced by different diaryldiazene units in order to get to various photoswitchable ligands. By this means the first photoswitchable GABA uptake inhibitors with distinctly enhanced potency upon photoirradiation could be obtained.

Erscheinungsdatum	23.05.2018
Reihe/Serie	Pharmazeutische Chemie
Verlagsort	München
Sprache	englisch
Maße	148 x 210 mm
Gewicht	252 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	GABA uptake inhibitors • Nipecotic acid derivatives • Photoswitchable compounds
ISBN-10	3-8439-3587-4 / 3843935874
ISBN-13	978-3-8439-3587-6 / 9783843935876
Zustand	Neuware