Teratogenicity Testing
Humana Press Inc. (Verlag)
978-1-4939-7882-3 (ISBN)
Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.
An Overview of Teratology.- Teratology Study Guidelines: An Overview.- Biological Concerns on the Selection of Animal Models for Teratogenic Testing.- The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells.- Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage.- Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs.- Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell.- Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs.- Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents.- Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology.- Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans.- Effect of Teratogens on Development of Drosophila melanogaster.- Cellular Responses in Drosophila melanogaster Following Teratogen Exposure.- Behavioral Teratogenesis in Drosophila melanogaster.- Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX.- Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays.- Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis.- Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development.- General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol.- Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio).- Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer.- Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure.- Omics in Zebrafish Teratogenesis.- Proteomic Analysis of Zebrafish (Danio rerio) after Chemical Exposure.- Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio).- Oxidative Stress Assessment in Zebrafish Larvae.- Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo.- Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus.- Histological and Histochemical Profile for Teratological Assessment in Mus musculus.- In Vivo Analysis of Apoptosis in Embryonic Hippocampus.- Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus.- Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse.- Methodology of Genotoxic and Teratogenic Studies in Rats.- Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos.- Glossary of Key Terms for Teratology.
| Erscheinungsdatum | 25.06.2018 |
|---|---|
| Reihe/Serie | Methods in Molecular Biology ; 1797 |
| Zusatzinfo | 85 Illustrations, color; 23 Illustrations, black and white; XV, 614 p. 108 illus., 85 illus. in color. With online files/update. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Schlagworte | Animal Models • Developmental Biology • Drug exposure • Embryo-fetal development • Fetotoxic effects • organogenesis • pharmaceuticals • Teratology • Toxicity |
| ISBN-10 | 1-4939-7882-9 / 1493978829 |
| ISBN-13 | 978-1-4939-7882-3 / 9781493978823 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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